Pancreatic pseudocyst

A pancreatic pseudocyst is a circumscribed collection of fluid rich in pancreatic enzymes, blood, and necrotic tissue, typically located in the lesser sac of the abdomen. Pancreatic pseudocysts are usually complications of pancreatitis,[4] although in children they frequently occur following abdominal trauma. Pancreatic pseudocysts account for approximately 75% of all pancreatic masses.[5]

Pancreatic pseudocyst
A pancreatic pseudocyst as seen on CT
CausesPancreatitis (chronic), Pancreatic neoplasm [1]
Diagnostic methodCyst fluid analysis[2]

Signs and symptoms

Signs and symptoms of pancreatic pseudocyst include abdominal discomfort and indigestion.[6]


Complications of pancreatic pseudocysts include infection, hemorrhage, obstruction and rupture. For obstruction, it can cause compression in the GI tract from the stomach to colon, compression in urinary system, biliary system, and arteriovenous system.


The cause of pancreatic pseudocyst can occur due to a variety of reasons, among them pancreatitis (chronic), pancreatic neoplasm and/or pancreatic trauma.[1]


Pancreatic pseudocysts are sometimes called false cysts because they do not have an epithelial lining. The wall of the pseudocyst is vascular and fibrotic, encapsulated in the area around the pancreas. Pancreatitis or abdominal trauma can cause its formation.[7] Treatment usually depends on the mechanism that brought about the pseudocyst. Pseudocysts take up to 6 weeks to completely form.[8]



Diagnosis of Pancreatic pseudocyst can be based on cyst fluid analysis:[2]

  • Carcinoembryonic antigen (CEA) and CEA-125 (low in pseudocysts and elevated in tumors);
  • Fluid viscosity (low in pseudocysts and elevated in tumors);
  • Amylase (usually high in pseudocysts and low in tumors)

The most useful imaging tools are:

  • Ultrasonography[9] – the role of ultrasonography in imaging the pancreas is limited by patient habitus, operator experience and the fact that the pancreas lies behind the stomach (and so a gas-filled stomach will obscure the pancreas).
  • Computerized tomography[10] – this is the gold standard for initial assessment and follow-up.
  • Magnetic resonance cholangiopancreatography (MRCP) – to establish the relationship of the pseudocyst to the pancreatic ducts, though not routinely used[11]


TPN formula

Pancreatic pseudocyst treatment should be aimed at avoiding any complication (1 in 10 cases become infected). They also tend to rupture, and have shown that larger cysts have a higher likelihood to become more symptomatic, even needing surgery.[12] If no signs of infection are present, initial treatment can include conservative measures such as bowel rest (NPO), parenteral nutrition (TPN), and observation. Serum amylase levels can be trended. If symptoms do not improve by 6 weeks, surgical intervention may be appropriate.

In the event of surgery:

  • Cystogastrostomy: In this surgical procedure a connection is created between the back wall of the stomach and the cyst such that the cyst drains into the stomach.[3]
  • Cystojejunostomy: In this procedure a connection is created between the cyst and the small intestine so that the cyst fluid directly into the small intestine.[13]
  • Cystoduodenostomy: In this procedure a connection is created between the duodenum (the first part of the intestine) and the cyst to allow drainage of the cyst content into duodenum.[14] The type of surgical procedure depends on the location of the cyst. For pseudocysts that occur in the head of the pancreas a cystduodenostomy is usually performed.[15]

See also


  1. Atluri, Pavan (2005-01-01). The Surgical Review: An Integrated Basic and Clinical Science Study Guide. Lippincott Williams & Wilkins. ISBN 9780781756419.
  2. "Pancreatic Pseudocysts: Practice Essentials, Background, Pathophysiology". 2018-10-30. Cite journal requires |journal= (help)
  3. (eds.), Edward H. Phillips ...; Rosenthal, Raul J. (1995). Operative strategies in laparoscopic surgery. Berlin [u.a.]: Springer. p. 136. ISBN 9783540592143. Retrieved 26 November 2017.CS1 maint: extra text: authors list (link)
  4. Habashi S, Draganov PV (January 2009). "Pancreatic pseudocyst". World J. Gastroenterol. 15 (1): 38–47. doi:10.3748/wjg.15.38. PMC 2653285. PMID 19115466. Archived from the original on 2014-10-12.
  5. Beger, Hans G.; Buchler, Markus; Kozarek, Richard; Lerch, Markus; Neoptolemos, John P.; Warshaw, Andrew; Whitcomb, David; Shiratori, Keiko (2009-01-26). The Pancreas: An Integrated Textbook of Basic Science, Medicine, and Surgery. John Wiley & Sons. ISBN 9781444300130.
  6. "Pancreatic pseudocyst: MedlinePlus Medical Encyclopedia". Retrieved 2015-08-10.
  7. Ignatavicius, Donna (2016). Medical surgical nursing. Elsevier. p. 1226. ISBN 978-1-4557-7255-1.
  8. LIllenoe, Keith (2013). Master techniques in Surgery. Lippincott Williams and Wilkins. p. 147. ISBN 978-1-60831-172-9.
  9. Aghdassi AA, Mayerle J, Kraft M, Sielenkämper AW, Heidecke CD, Lerch MM (2006). "Pancreatic pseudocysts - when and how to treat?". HPB (Oxford). 8 (6): 432–41. doi:10.1080/13651820600748012. PMC 2020756. PMID 18333098.
  10. Aghdassi A, Mayerle J, Kraft M, Sielenkämper AW, Heidecke CD, Lerch MM (March 2008). "Diagnosis and treatment of pancreatic pseudocysts in chronic pancreatitis". Pancreas. 36 (2): 105–12. doi:10.1097/MPA.0b013e31815a8887. PMID 18376299.
  11. Khanna, A. K.; Tiwary, Satyendra K.; Kumar, Puneet (2012). "Pancreatic Pseudocyst: Therapeutic Dilemma". International Journal of Inflammation. 2012: 1–7. doi:10.1155/2012/279476. PMC 3345229. PMID 22577595.
  12. "Pancreatic pseudocyst Treatment". eMedicine. Retrieved August 11, 2015.
  13. Hughes, Steven (2015-03-26). Operative Techniques in Hepato-Pancreato-Biliary Surgery. Lippincott Williams & Wilkins. ISBN 9781496319067.
  14. Skandalakis, Lee J.; Skandalakis, John E. (2013-11-08). Surgical Anatomy and Technique: A Pocket Manual. Springer Science & Business Media. ISBN 9781461485636.
  15. Scott-Conner, Carol (2009). Scott-Conner & Dawson: Essential Operative Techniques and Anatomy. Lippincott Williams and Wilkins. p. 455. ISBN 978-1-4511-5172-5.

Further reading

External resources
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.