U-77891

U-77891 is an opioid analgesic drug that was first synthesized in 1983 by the Upjohn company.[1] It was originally synthesized to prove that the removal of a single methylene spacer of the benzamide would alter a κ-opioid receptor agonist such as U-50488 into an μ-opioid receptor agonist, as well as producing a semi-rigid derivative of U-47700. This would help elucidate the relative positions of the hydrogen-bond acceptors and substituted aromatic system to find the compound with the lowest Ki value in a series of benzamide opioids dating back to the 1970s.[2] The original work found a mixture of agonists and antagonists.[3]

U-77891
Clinical data
Routes of
administration		oral, parenteral
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC18H24Br2N2O
Molar mass444.211 g·mol−1
3D model (JSmol)

U-77891 acts as an agonist of the μ-opioid, δ-opioid and κ-opioid receptors with Ki values of 2, 105 and 2300 nM, respectively.[2] The compound has ED50 values of 0.02 mg/kg and 0.21 mg/kg in mouse phenylquinone writhing and tail-flick assays.[2] One reason for the high potency is the LogP of 4.57,[4] allowing it to accumulate in fatty tissue such as the brain.

References
  1. Jacob Szmuszkovicz, John M. McCall, Lester J. Kaplan, Moses W. McMillan (18 May 1983). "US Patent 4598088 - 2-pyrrolyl-cycloalkyl-amide analgesics". The Upjohn Company.CS1 maint: multiple names: authors list (link)
  2. Roger A. Fujimoto; Jerome Boxer; Robert H. Jackson; John P. Simke; Robert F. Neale; Elaine W. Snowhill; Beverly J. Barbaz; Michael Williams; Matthew A. Sills (June 1989). "Synthesis, opioid receptor binding profile, and antinociceptive activity of 1-azaspiro[4.5]decan-10-yl amides". Journal of Medicinal Chemistry. 32 (6): 1259–1265. doi:10.1021/jm00126a019. PMID 2542556.
  3. Moses W. McMillan, Jacob Szmuszkovicz (9 April 1981). "US Patent 4466977 - N-[2-Amino(oxy- or thia- group-substituted-cycloaliphatic)]benzeneacetamides and -benzamide analgesics". The Upjohn Company.
  4. "Properties Viewer". chemicalize.org.

See also


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