Semorphone
Semorphone (Mr 2264) is an opiate analogue that is an N-substituted derivative of oxymorphone.
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| Formula | C19H23NO5 |
| Molar mass | 345.395 g·mol−1 |
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Semorphone is a partial agonist at μ-opioid receptors. It is around twice the potency of morphine, but with a ceiling effect on both analgesia and respiratory depression[1] which means that these effects stop becoming any stronger after a certain maximum dose.
It is not currently used in medicine, and is not a controlled drug, although it might be considered to be a controlled substance analogue of oxymorphone on the grounds of its related chemical structure in some jurisdictions such as the United States, Canada, Australia and New Zealand.
References
- Behne, M.; Bremerich, D.; Heinrich, J.; Schumacher, H.; Scherer, M. (1994). "Respiratory effects and tolerability of Mr 2264 Cl". European Journal of Clinical Pharmacology. 46 (4). doi:10.1007/BF00194395.
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