SN 35210
SN 35210 is an arylcyclohexylamine dissociative anesthetic drug. It was derived from ketamine with the intention of producing a shorter acting agent more suitable to be used as a stand-alone drug, whereas ketamine itself generally has to be used in combination with other drugs such as midazolam to minimise the occurrence of emergence reactions due to its hallucinogenic side effects. In common with other short-acting anaesthetic drugs such as remifentanil and remimazolam, SN 35210 has had the chemical structure modified to incorporate a methyl ester group which is rapidly metabolised to a carboxylic acid, producing an inactive compound and thus rapidly terminating the effects of the drug. It was selected for development from a series of structurally related alkyl esters due to having the shortest duration of action and the most similar pharmacological profile to ketamine itself.[1][2][3]
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| Formula | C18H24ClNO3 |
| Molar mass | 337.841 g/mol g·mol−1 |
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References
- Jose, J.; Gamage, S. A.; Harvey, M. G.; Voss, L. J.; Sleigh, J. W.; Denny, W. A. (2013). "Structure-activity relationships for ketamine esters as short-acting anaesthetics". Bioorganic & Medicinal Chemistry. 21 (17): 5098–106. doi:10.1016/j.bmc.2013.06.047. PMID 23876339.
- Harvey, M.; Sleigh, J.; Voss, L.; Jose, J.; Gamage, S.; Pruijn, F.; Liyanage, S.; Denny, W. (2015). "Development of Rapidly Metabolized and Ultra-Short-Acting Ketamine Analogs". Anesthesia and Analgesia. 121 (4): 925–33. doi:10.1213/ANE.0000000000000719. PMID 25822925.
- Harvey, M; Sleigh, J; Voss, L; Pruijn, F; Jose, J; Gamage, S; Denny, W (2015). "Determination of the Hypnotic Potency in Rats of the Novel Ketamine Ester Analogue SN 35210". Pharmacology. 96 (5–6): 226–32. doi:10.1159/000439598. PMID 26352278.