Proheptazine

Proheptazine is an opioid analgesic from the phenazepine family. It was invented in the 1960s.[1]

Proheptazine
Clinical data
ATC code
  • none
Legal status
Legal status
  • AU: S9 (Prohibited)
  • CA: Schedule I
  • DE: Anlage I (Authorized scientific use only)
  • US: Schedule I
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ECHA InfoCard100.000.916
Chemical and physical data
FormulaC17H25NO2
Molar mass275.39 g/mol g·mol−1
3D model (JSmol)
  (verify)

Proheptazine produces similar effects to other opioids, including analgesia, sedation, euphoria, dizziness and nausea.

In the United States it is a Schedule I Narcotic controlled substance with an ACSCN of 9643 and a 2013 annual aggregate manufacturing quota of zero. The salts in use are the citrate (free base conversion ratio 0.589), hydrobromide (0.773), and hydrochloride (0.883).[2][3]

References
  1. Diamond J, Bruce WF, Tyson FT. Synthesis and Properties of the Analgesic DL-α-1,3-dimethyl-4-phenyl-4-propionoxyazacycloheptane (Proheptazine). Journal of Medicinal Chemistry. 1964 Jan;7:57-60.
  2. http://www.deadiversion.usdoj.gov/fed_regs/quotas/2014/fr0825.htm
  3. http://www.deadiversion.usdoj.gov/quotas/conv_factor/index.html



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