List of investigational antipsychotics
This is a list of investigational antipsychotics, or antipsychotics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Receptor modulators
Monoamine receptor modulators
- ATI-9242 – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)
- AVN-211 (CD-008-0173) – 5-HT6 receptor antagonist
- Brilaroxazine (RP-5063, RP-5000; oxaripiprazole) – atypical antipsychotic (D2 receptor partial agonist, 5-HT2A receptor antagonist, other actions)
- F-17464 – D3 receptor antagonist, 5-HT1A receptor partial agonist, and weak D2 receptor partial agonist
- FKF-02SC (TGOF-02N) – atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions)
- Lu-AF35700 – D1, 5-HT2A, and 5-HT6 receptor antagonist
- Lumateperone (ITI-007, ITI-722) – atypical antipsychotic (D2 receptor partial agonist, 5-HT2A receptor antagonist, other actions)
- Masupirdine (SUVN-502) – 5-HT6 receptor antagonist
- Pimavanserin (ACP-103, BVF-048; Nuplazid) – 5-HT2A receptor inverse agonist
- SEP-363856 (SEP-856) – 5-HT1A receptor and TAAR1 agonist
- SUVN-D4010 – 5-HT4 receptor partial agonist
- TAK-058 (ENV-8058) – 5-HT3 receptor antagonist
Glutamate receptor modulators
- Neboglamine (CR-2249, XY-2401; nebostinel) – NMDA receptor glycine-site positive allosteric modulator
- PF-4958242 – AMPA receptor positive allosteric modulator
- Pomaglumetad methionil (DB-103, LY-2140023, LY-2812223) – mGluR2 and mGluR3 agonist
Acetylcholine receptor modulators
- APN-1125 – α7 nicotinic acetylcholine receptor partial agonist
- Trospium chloride/xanomeline (KarXT) – combined M1 and M4 muscarinic acetylcholine receptor agonist and peripherally-selective muscarinic acetylcholine receptor antagonist
Cannabinoid receptor modulators
- AX-1604 – cannabinoid receptor modulator (phytocannabinoid-based chewing gum)
- Cannabidiol (CBD; GW-42003, GWP-42003, GWP-42003-P, ECP-012A; Arvisol, Epidiolex) – cannabinoid receptor modulator, antioxidant, other actions
Other/mixed receptor modulators
- Basmisanil (RG-1662, RO-5186582) – GABAA receptor α5 subunit-containing negative allosteric modulator
- Deudextromethorphan (d-DM; AVP-786, CTP-786) – σ1 receptor agonist, serotonin–norepinephrine reuptake inhibitor, uncompetitive NMDA receptor antagonist, other actions
- Erteberel (LY-500307, SERBA-1) – ERβ agonist
- Olanzapine/samidorphan (ALKS-3831) – combined atypical antipsychotic (D2 and 5-HT2A receptor antagonist, other actions) and μ-opioid receptor antagonist
- Roluperidone (CYR-101, MIN-101, MT-210) – 5-HT2A and σ2 receptor antagonist
Enzyme inhibitors
- BI-409306 (SUB-166499) – phosphodiesterase 9A inhibitor
- Lu-AF11167 – dual phosphodiesterase 2A and 10A inhibitor
- OMS-824 (OMS-643762) – phosphodiesterase 10A inhibitor
- Sodium benzoate (SND-11, SND-12, SND-13, SND-14; Clozaben, NaBen) – D-amino acid oxidase inhibitor
- TAK-831 – D-amino acid oxidase inhibitor
Ion channel modulators
- AUT-00206 – shaw potassium channel modulator
- Evenamide (NW-3509; NW-3509A) – Nav1.3, Nav1.7, and Nav1.8 voltage-gated sodium channel blocker
Others
- ADE-615 – undefined mechanism of action
- ADE-616 – undefined mechanism of action
- AMG-581 – undefined mechanism of action
- ASP-4345 – undefined mechanism of action
- ASP-6981 – undefined mechanism of action
- ATx11-004 – undefined mechanism of action
- MK-8189 – undefined mechanism of action
- PF-06266047 – undefined mechanism of action
- Pyridoxamine (BST-4001, K-163, K-163SZ; Pyridorin) – vitamin B6, advanced glycosylation end-product inhibitor, oxygen radical scavenger
- RG-7906 – undefined mechanism of action
- TS-134 (TS-1341) – undefined mechanism of action
See also
References
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