ML-154

ML-154
Clinical data
ATC code	none;
Identifiers
	IUPAC name 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide;
CAS Number	1345964-89-7;
PubChem CID	46930969;
ChemSpider	26360842;
Chemical and physical data
Formula	C29H26BrN2PS
Molar mass	545.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Br-].C1(=CC=CC=C1)[P](=S)(C2=C([N+](=C3C=CC=C[N]23)C\C=C\C4=CC=CC=C4)C)C5=CC=CC=C5;
	InChI InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+;; Key:CJAQCMBWGUOBIX-ZUQRMPMESA-M;

ML-154 (NCGC-84) is a drug which acts as a selective, non-peptide antagonist at the neuropeptide S receptor NPSR.[1] In animal studies it decreases self-administration of alcohol in addicted rats, and lowers motivation for alcohol rewards, suggesting a potential application for NPS antagonists in the treatment of alcoholism.[2]

References

Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, et al. (November 2013). "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry. 56 (22): 9045–56. doi:10.1021/jm400904m. PMC 4877059. PMID 24171469.
Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, et al. (June 2013). "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience. 33 (24): 10132–42. doi:10.1523/JNEUROSCI.4742-12.2013. PMID 23761908.

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[1] Patnaik S, Marugan JJ, Liu K, Zheng W, Southall N, Dehdashti SJ, et al. (November 2013). "Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor". Journal of Medicinal Chemistry. 56 (22): 9045–56. doi:10.1021/jm400904m. PMC 4877059. PMID 24171469.

[2] Thorsell A, Tapocik JD, Liu K, Zook M, Bell L, Flanigan M, et al. (June 2013). "A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK-phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats". The Journal of Neuroscience. 33 (24): 10132–42. doi:10.1523/JNEUROSCI.4742-12.2013. PMID 23761908.

ML-154

See also

References