CTN-986

CTN-986
Names
	Other names 3-[(O-D-apio-β-D-furanosyl-(1→2)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-β-D-glucopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; Quercetin 3-O-b-d-apiofuranosyl-(1→2)-[a-l-rhamnopyranosyl-(1→6)]-b-d-glucopyranoside
Identifiers
CAS Number	63947-67-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	24844836;
PubChem CID	44259159;
CompTox Dashboard (EPA)	DTXSID20658067 ;
	InChI InChI=1S/C32H38O20/c1-10-19(38)22(41)24(43)29(48-10)46-7-17-20(39)23(42)27(52-31-28(44)32(45,8-33)9-47-31)30(50-17)51-26-21(40)18-15(37)5-12(34)6-16(18)49-25(26)11-2-3-13(35)14(36)4-11/h2-6,10,17,19-20,22-24,27-31,33-39,41-45H,7-9H2,1H3/t10-,17+,19-,20+,22+,23-,24+,27+,28-,29+,30-,31-,32+/m0/s1 Key: UPVDFUGORYNXMW-VCKCKQTPSA-N; InChI=1/C32H38O20/c1-10-19(38)22(41)24(43)29(48-10)46-7-17-20(39)23(42)27(52-31-28(44)32(45,8-33)9-47-31)30(50-17)51-26-21(40)18-15(37)5-12(34)6-16(18)49-25(26)11-2-3-13(35)14(36)4-11/h2-6,10,17,19-20,22-24,27-31,33-39,41-45H,7-9H2,1H3/t10-,17+,19-,20+,22+,23-,24+,27+,28-,29+,30-,31-,32+/m0/s1 Key: UPVDFUGORYNXMW-VCKCKQTPBC;
	SMILES OC1=CC(O)=C(C(C(O[C@H]2[C@H](O[C@@]3([H])[C@H](O)[C@@](O)(CO)CO3)[C@@H](O)[C@H](O)[C@@H](CO[C@H]4[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)O2)=C(C5=CC=C(O)C(O)=C5)O6)=O)C6=C1;
Properties
Chemical formula	C32H38O20
Molar mass	742.636 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

CTN-986 is a glycoside of quercetin found in cottonseeds and cottonseed oil. In a rodent model, it displays some antidepressant-like properties and stimulation of neurogenesis in the hippocampus.[1] The neurogenesis appears to be mediated by activation of the 5-HT_1A receptor, as co-administration with the 5-HT_1A antagonist WAY-100,635 abolished the effect.[1]

References

Zhang LM, Zhang YZ, Liu YQ, Gong ZH, Zhao YM, Li YF (2009). "CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro". Eur J Pharmacol. 607: 110–113. doi:10.1016/j.ejphar.2008.12.052. PMID 19326568.

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[pmid19326568-1] Zhang LM, Zhang YZ, Liu YQ, Gong ZH, Zhao YM, Li YF (2009). "CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro". Eur J Pharmacol. 607: 110–113. doi:10.1016/j.ejphar.2008.12.052. PMID 19326568.

CTN-986

See also

References