Cefditoren

Cefditoren ie:(Cefditor)is a third-generation cephalosporin antibiotic for oral use.

Cefditoren
Clinical data
Trade namesSpectracef, others
AHFS/Drugs.comMonograph
MedlinePlusa605003
Routes of
administration		By mouth
ATC code
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC19H18N6O5S3
Molar mass506.58 g/mol g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

Cefditor has an unique action that is Lowering IL6 &K L6 to get rid from lung inflammation and epithelial damage besides bactericidal activity.

It was patented in 1984 and approved for medical use in 1994.[1]

Medical uses

Cefditoren pivoxil is used to treat uncomplicated skin and skin structure infections, community-acquired pneumonia, acute bacterial exacerbation of chronic bronchitis, pharyngitis, and tonsillitis.

Spectrum of bacterial susceptibility

Cefditoren pivoxil has a broad spectrum of activity and has been used to treat bacterial infections of the skin and respiratory tract, including bronchitis, pneumonia, and tonsillitis. The following represents MIC susceptibility data for a few medically significant microorganisms.

  • Haemophilus influenzae: ≥0.063 – 0.25 μg/ml
  • Staphylcoccus aureus: 0.25 – >128 μg/ml (includes MRSA)
  • Streptococcus pyogenes: ≤0.004 – 2 μg/ml[2]

Cefditoren is a broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, but does not have antibacterial activity against Pseudomonas aeruginosa.[3]

Names

Cefditoren pivoxil is the active ingredient in Spectracef and is available as 200- and 400-mg tablets. Cefditoren pivoxil is a prodrug which is metabolized in the body to release cefditoren as the active metabolite.

It is commonly marketed under the trade name Spectracef by Vansen Pharma Inc. Cefditoren is also marketed under the name Meiact by Meiji Seika Pharma Co., Ltd.[4]

References
  1. Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 496. ISBN 9783527607495.
  2. http://www.toku-e.com/Assets/MIC/Cefditoren%20sodium.pdf
  3. "Disease relevance of Cefditoren". Retrieved June 24, 2014.
  4. Meiact Full Description Archived 2010-09-17 at the Wayback Machine

https://www.accessdata.fda.gov/drugsatfda_docs/nda/2001/21-222_Spectracef.cfm

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