Normustine

Normustine
Clinical data
Other names	Bis(2-chloroethyl)carbamic acid
Identifiers
	IUPAC name Bis(2-chloroethyl)carbamic acid;
CAS Number	78619-95-1;
PubChem CID	18377863;
UNII	Q2KPX8TH4K;
Chemical and physical data
Formula	C5H9Cl2NO2
Molar mass	186.032 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C(CCl)N(CCCl)C(=O)O;
	InChI InChI=1S/C5H9Cl2NO2/c6-1-3-8(4-2-7)5(9)10/h1-4H2,(H,9,10); Key:TTYAKTJQJVVKED-UHFFFAOYSA-N;

Normustine, also known as bis(2-chloroethyl)carbamic acid, is a nitrogen mustard and alkylating antineoplastic agent (i.e., chemotherapy agent).[1][2][3] It is a metabolite of a number of antineoplastic agents that have been developed for the treatment of tumors, including estramustine phosphate, alestramustine, cytestrol acetate, and ICI-85966 (stilbostat), but only the former of which has actually been marketed.[1][2][3]

References

Laurence Brunton; Bruce Chabner; Bjorn Knollman (14 January 2011). Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition. McGraw Hill Professional. p. 1709. ISBN 978-0-07-176939-6.
Brian W. Fox; M. Fox (6 December 2012). Antitumor Drug Resistance. Springer Science & Business Media. pp. 199–. ISBN 978-3-642-69490-5.
Michael Decker (5 April 2017). Design of Hybrid Molecules for Drug Development. Elsevier Science. pp. 201–. ISBN 978-0-08-101118-8.

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