Masoprocol
Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.
Clinical data | |
---|---|
Trade names | Actinex |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Pregnancy category |
|
Routes of administration | Topical |
ATC code | |
Pharmacokinetic data | |
Bioavailability | Very low |
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.044.172 |
Chemical and physical data | |
Formula | C18H22O4 |
Molar mass | 302.365 g/mol g·mol−1 |
3D model (JSmol) | |
SMILES
| |
InChI
| |
|
Also called nordihydroguaiaretic acid, NDGA, and actinex.
Mechanism
Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.
It is a lipoxygenase inhibitor.[1]
References
- "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827.
External links
- MedlinePlus Drug Information
- Actinex entry in the public domain NCI Cancer Dictionary
This article is issued from
Wikipedia.
The text is licensed under Creative
Commons - Attribution - Sharealike.
Additional terms may apply for the media files.