Masoprocol

Masoprocol is an antineoplastic drug used to treat skin growths caused by sun exposure. A form of nordihydroguaiaretic acid that is taken by mouth is being studied in the treatment of prostate cancer.

Masoprocol
Clinical data
Trade namesActinex
AHFS/Drugs.comMicromedex Detailed Consumer Information
Pregnancy
category
  • US: B (No risk in non-human studies)
    Routes of
    administration
    Topical
    ATC code
    Pharmacokinetic data
    BioavailabilityVery low
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.044.172
    Chemical and physical data
    FormulaC18H22O4
    Molar mass302.365 g/mol g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    Also called nordihydroguaiaretic acid, NDGA, and actinex.

    Mechanism

    Nordihydroguaiaretic acid is an antioxidant, and it may block certain enzymes needed for tumor growth.

    It is a lipoxygenase inhibitor.[1]

    References

    1. "Masoprocol decreases rat lipolytic activity by decreasing the phosphorylation of HSL". Am. J. Physiol. Endocrinol. Metab. 279 (3): E593–600. September 2000. PMID 10950827.



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