Treosulfan

Treosulfan
Clinical data
Other names	1,2,3,4-Butanetetrol, 1,4-dimethanesulfonate, Threitol 1,4-dimethanesulfonate, Threitol 1,4-bismethanesulfonate; L-Threitol 1,4-bis(methanesulfonate); Ovastat; Threosulphan; Treosulphan; Tresulfan
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral, IV
ATC code	L01AB02 (WHO) ;
Identifiers
	IUPAC name (2S,3S)-2,3-Dihydroxybutane-1,4-diyl dimethanesulfonate;
CAS Number	299-75-2 ;
PubChem CID	9296;
ChemSpider	8057780;
UNII	CO61ER3EPI;
CompTox Dashboard (EPA)	DTXSID0026173 ;
ECHA InfoCard	100.005.529
Chemical and physical data
Formula	C6H14O8S2
Molar mass	278.30056 g·mol−1 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	101.5 to 105 °C (214.7 to 221.0 °F)
	SMILES CS(=O)(=O)OC[C@@H]([C@H](COS(=O)(=O)C)O)O;
	InChI InChI=1S/C6H14O8S2/c1-15(9,10)13-3-5(7)6(8)4-14-16(2,11)12/h5-8H,3-4H2,1-2H3/t5-,6-/m0/s1; Key:YCPOZVAOBBQLRI-WDSKDSINSA-N;
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Treosulfan is a substance that is being studied in the treatment of cancer.[1] It belongs to the family of drugs called alkylating agents. It has been used mainly as a substitute of busulfan in frail patients, as the side effects and toxicity are supposedly less severe.

References

Schmittel A, Schmidt-Hieber M, Martus P, et al. (December 2006). "A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma". Ann. Oncol. 17 (12): 1826–9. doi:10.1093/annonc/mdl309. PMID 16971664.

External links

Treosulfan entry in the public domain NCI Dictionary of Cancer Terms

This article incorporates public domain material from the U.S. National Cancer Institute document "Dictionary of Cancer Terms".

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[pmid16971664-1] Schmittel A, Schmidt-Hieber M, Martus P, et al. (December 2006). "A randomized phase II trial of gemcitabine plus treosulfan versus treosulfan alone in patients with metastatic uveal melanoma". Ann. Oncol. 17 (12): 1826–9. doi:10.1093/annonc/mdl309. PMID 16971664.