Dieulafoy's lesion

Dieulafoy's lesion is a medical condition characterized by a large tortuous arteriole most commonly in the stomach wall (submucosal) that erodes and bleeds. It can present in any part of the gastrointestinal tract.[1] It can cause gastric hemorrhage[2] but is relatively uncommon. It is thought to cause less than 5% of all gastrointestinal bleeds in adults. It was named after French surgeon Paul Georges Dieulafoy, who described this condition in his paper "Exulceratio simplex: Leçons 1-3" in 1898.[3][4] It is also called "caliber-persistent artery" or "aneurysm" of gastric vessels. However, unlike most other aneurysms, these are thought to be developmental malformations rather than degenerative changes.

Dieulafoy's lesion
Other namesExulceratio simplex Dieulafoy
Blood supply of stomach

Signs and symptoms

The symptoms due to bleeding are hematemesis and/or melena.[1]

Presenting Symptoms
Recurrent hematemesis with melena 51% of cases
Hematemesis without melena 28% of cases
Melena with no hematemesis 18% of cases

A Dieulafoy's lesion is difficult to diagnose, because of the intermittent pattern of bleeding. Endoscopically it is not easy to recognize and therefore sometimes multiple views have to be performed over a longer period. Today angiography is a good additional diagnostic, but then it can only be seen during a bleeding at that exact time.


In contrast to peptic ulcer disease, a history of alcohol abuse or NSAID use is usually absent in DL.

Dieulafoy's lesions occur twice as often in men as women and people typically have multiple comorbidities, including hypertension, cardiovascular disease, chronic kidney disease, and diabetes.


Dieulafoy's lesions are characterized by a single large tortuous small artery[5] in the submucosa which does not undergo normal branching or a branch with caliber of 1–5 mm (more than 10 times the normal diameter of mucosal capillaries). The lesion bleeds into the gastrointestinal tract through a minute defect in the mucosa which is not a primary ulcer of the mucosa but an erosion likely caused in the submucosal surface by protrusion of the pulsatile arteriole.

Approximately 75% of Dieulafoy's lesions occur in the upper part of the stomach within 6 cm of the gastroesophageal junction, most commonly in the lesser curvature. Extragastric lesions have historically been thought to be uncommon but have been identified more frequently in recent years, likely due to increased awareness of the condition. The duodenum is the most common location (14%) followed by the colon (5%), surgical anastamoses (5%), the jejunum (1%) and the esophagus (1%).[6] The pathology in these extragastric locations is essentially the same as that of the more common gastric lesion.


It is diagnosed and treated endoscopically; however, endoscopic ultrasound or angiography can be of benefit.

Endoscopic techniques used in the treatment include epinephrine injection followed by bipolar or monopolar electrocoagulation, injection sclerotherapy, heater probe, laser photocoagulation, hemoclipping or banding. Alternatively, in patients with refractory bleeding Interventional Radiology may be consulted for an angiogram with subselective embolization.[7]


The mortality rate for Dieulafoy's was much higher before the era of endoscopy, where open surgery was the only treatment option.


  1. al-Mishlab T, Amin AM, Ellul JP (August 1999). "Dieulafoy's lesion: an obscure cause of GI bleeding". Journal of the Royal College of Surgeons of Edinburgh. 44 (3): 222–5. PMID 10453143.
  2. Akhras J, Patel P, Tobi M (March 2007). "Dieulafoy's lesion-like bleeding: an underrecognized cause of upper gastrointestinal hemorrhage in patients with advanced liver disease". Dig. Dis. Sci. 52 (3): 722–6. doi:10.1007/s10620-006-9468-7. PMID 17237996.
  3. synd/3117 at Who Named It?
  4. G. Dieulafoy. Exulceratio simplex: Leçons 1-3. In: G. Dieulafoy, editor: Clinique medicale de l'Hotel Dieu de Paris. Paris, Masson et Cie: 1898:1-38.
  5. Eidus, LB.; Rasuli, P.; Manion, D.; Heringer, R. (Nov 1990). "Caliber-persistent artery of the stomach (Dieulafoy's vascular malformation)". Gastroenterology. 99 (5): 1507–10. PMID 2210260.
  6. Lee Y, Walmsley R, Leong R, Sung J (2003). "Dieulafoy's Lesion". Gastrointestinal Endoscopy. 58 (2): 236–243. doi:10.1067/mge.2003.328. PMID 12872092.
  7. Navuluri, Rakesh; Kang, Lisa; Patel, Jay; Van Ha, Thuong (2012-09-01). "Acute Lower Gastrointestinal Bleeding". Seminars in Interventional Radiology. 29 (3): 178–186. doi:10.1055/s-0032-1326926. ISSN 0739-9529. PMC 3577586. PMID 23997409.
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