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Risk Factors

Certain factors have been shown to be associated with a greater risk of arthritis. Some of these risk factors are modifiable while others are not.

Non-modifiable risk factors

  • Age: The risk of developing most types of arthritis increases with age.
  • Gender: Most types of arthritis are more common in women; 52% of all adults with arthritis are women. Gout is more common in men.
  • Genetic: Specific genes are associated with a higher risk of certain types of arthritis, such as rheumatoid arthritis (RA), systemic lupus erythematous (SLE), and ankylosing spondylitis.

Modifiable risk factors

  • Overweight and Obesity: Excess weight can contribute to both the onset and progression of knee osteoarthritis.
  • Joint Injuries: Damage to a joint can contribute to the development of osteoarthritis in that joint.
  • Infection: Many microbial agents can infect joints and potentially cause the development of various forms of arthritis.
  • Occupation: Certain occupations involving repetitive knee bending and squatting are associated with osteoarthritis of the knee.
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