Prednicarbate

Prednicarbate
Clinical data
Other names	{2-[(8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl} propanoate
AHFS/Drugs.com	Monograph
MedlinePlus	a604021
Routes of; administration	Topical
ATC code	D07AC18 (WHO) ;
Identifiers
	IUPAC name 17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-3,20-dioxopregna-1,4-dien-21-yl propionate;
CAS Number	73771-04-7 ;
PubChem CID	6714002;
IUPHAR/BPS	7605;
DrugBank	DB01130 ;
ChemSpider	5145991 ;
UNII	V901LV1K7D;
ChEMBL	ChEMBL1200386 ;
CompTox Dashboard (EPA)	DTXSID9045502 ;
ECHA InfoCard	100.070.516
Chemical and physical data
Formula	C27H36O8
Molar mass	488.577 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC(=O)[C@@]1(OC(=O)OCC)CC[C@H]2[C@H]4[C@H]([C@@H](O)C[C@]12C)[C@]/3(/C=C\C(=O)\C=C\3CC4)C)CC;
	InChI InChI=1S/C27H36O8/c1-5-22(31)34-15-21(30)27(35-24(32)33-6-2)12-10-19-18-8-7-16-13-17(28)9-11-25(16,3)23(18)20(29)14-26(19,27)4/h9,11,13,18-20,23,29H,5-8,10,12,14-15H2,1-4H3/t18-,19-,20-,23+,25-,26-,27-/m0/s1 ; Key:FNPXMHRZILFCKX-KAJVQRHHSA-N ;
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Prednicarbate is a relatively new topical corticosteroid drug. It is similar in potency to hydrocortisone. Compared to other topical corticosteroids, like betamethasone, repeated prednicarbate use does not cause skin atrophy as quickly. Corticosteroids have always been an important part of the pharmacological arsenal of dermatology; however, their tendency to produce side-effects has caused the need to search for new preparations.

It is nonhalogenated.[1]

References

Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.

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[pmid15657633-1] Gupta AK, Chow M (2004). "A review of prednicarbate (Dermatop)". Skin Therapy Lett. 9 (10): 5–6, 9. PMID 15657633.