Alclometasone

Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.[2]

Alclometasone
Clinical data
Trade namesAclovate
AHFS/Drugs.comMonograph
MedlinePlusa604021
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		Topical
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Bioavailability3% systemically (topical)
    MetabolismHepatic
    Onset of actionEczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days [1]
    Identifiers
    CAS Number
    PubChem CID
    DrugBank
    ChemSpider
    UNII
    ChEBI
    ChEMBL
    Chemical and physical data
    FormulaC22H29ClO5
    Molar mass408.92 g·mol−1
    3D model (JSmol)
     NY (what is this?)  (verify)

    The prodrug alclometasone dipropionate was originally marketed under the brand name Aclovate by GlaxoSmithKline as a topical cream and ointment. However, generic versions of the drug are available.

    Medical uses

    Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:

    Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.

    Contraindications
    • hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
    • cutaneous tuberculosis
    • chicken pox
    • perioral dermatitis
    • acne
    • rosacea
    • open wounds
    • trophic ulcers
    • viral infection of skin
    • skin manifestations of syphilis

    Side effects

    Adverse reactions (sometimes, less than 1-2% cases) include:

    Pharmacology

    Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 – the enzyme responsible for the synthesis of arachidonic acid. Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be produced.

    Alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g., cytokines, histamine, leukotrienes, serotonin).

    Formulations

    Alclometasone as Aclovate is supplied in:

    • Cream; Topical; 0.05%
    • Ointment; Topical; 0.05%

    References
    1. "Alclometasone - Professional Patient Advice". Drugs.com. Retrieved 29 December 2017.
    2. "Alclometasone - FDA Prescribing Information". Drugs.com. Retrieved 29 December 2017.
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