Diflorasone diacetate

Diflorasone diacetate
Clinical data
Trade names	Psorcon
AHFS/Drugs.com	Monograph
MedlinePlus	a602019
Pregnancy; category	US: C (Risk not ruled out) ;
Routes of; administration	Topical
ATC code	D07AC10 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name [17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate;
CAS Number	2557-49-5 ;
PubChem CID	71414;
IUPHAR/BPS	7068;
DrugBank	DB00223 ;
ChemSpider	64504 ;
UNII	T2DHJ9645W;
KEGG	D01327 ;
ChEBI	CHEBI:31483 ;
ChEMBL	ChEMBL1201380 ;
CompTox Dashboard (EPA)	DTXSID8045646 ;
ECHA InfoCard	100.046.872
Chemical and physical data
Formula	C26H32F2O7
Molar mass	494.525 g/mol g·mol−1
	InChI InChI=1S/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(31)6-7-23(19,4)25(18,28)21(32)11-24(17,5)26(13,35-15(3)30)22(33)12-34-14(2)29/h6-7,9,13,17-18,20-21,32H,8,10-12H2,1-5H3/t13-,17-,18-,20-,21-,23-,24-,25-,26-/m0/s1 ; Key:BOBLHFUVNSFZPJ-JOYXJVLSSA-N ;
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Diflorasone diacetate is a topical steroid that comes in the form of a cream. It is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I corticosteroid [of classes I – VII] in the United States.[2]

No long-term animal studies have been done to determine whether diflorasone diacetate could have carcinogenic properties.

Little data is available regarding whether diflorasone diacetate would be present in great enough quantities to cause harm to an infant.[3]

References

Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–132. doi:10.1159/000247323. PMID 8428041.
psoriasis.org: [www.psoriasis.org/sublearn03_mild_potency]
Drugs.com: Diflorasone topical

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[1] Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology. 186 (2): 129–132. doi:10.1159/000247323. PMID 8428041.

[psoriasis.org-2] soriasis.org: [www.psoriasis.org/sublearn03_mild_potency]

[Drugs.com-3] Drugs.com: Diflorasone topical