Domoprednate

Domoprednate
Clinical data
Trade names	Stermonid
Other names	Ro 12-7024; 11β-Hydroxy-D-homopregna-1,4-diene-3,20-dione 17α-butyrate
Routes of; administration	Topical
Drug class	Corticosteroid; Glucocorticoid
Identifiers
	IUPAC name [(1R,4aS,4bS,10aR,10bS,11S,12aS)-1-Acetyl-11-hydroxy-10a,12a-dimethyl-8-oxo-2,3,4,4a,4b,5,6,10b,11,12-decahydrochrysen-1-yl] butanoate;
CAS Number	66877-67-6;
PubChem CID	68868;
ChemSpider	62100;
UNII	910G0QIM2M;
ChEMBL	ChEMBL2106538;
ECHA InfoCard	100.060.441
Chemical and physical data
Formula	C26H36O5
Molar mass	428.569 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCC(=O)O[C@@]1(CCC[C@@H]2[C@@]1(C[C@@H]([C@H]3[C@H]2CCC4=CC(=O)C=C[C@]34C)O)C)C(=O)C;
	InChI InChI=1S/C26H36O5/c1-5-7-22(30)31-26(16(2)27)12-6-8-20-19-10-9-17-14-18(28)11-13-24(17,3)23(19)21(29)15-25(20,26)4/h11,13-14,19-21,23,29H,5-10,12,15H2,1-4H3/t19-,20-,21-,23+,24-,25-,26-/m0/s1; Key:IYBYNRHXGXDDDS-VRRJBYJJSA-N;

Domoprednate (brand name Stermonid; developmental code name Ro 12-7024) is a synthetic glucocorticoid corticosteroid which was developed in the late 1970s and 1980s.[1][2][3][4][5]

References

J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 465–. ISBN 978-1-4757-2085-3.
Schmidt H, Hjorth N, Holm P (1984). "A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses". Dermatologica. 168 (3): 127–30. PMID 6370748.
Serup J, Holm P (1985). "Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo". Dermatologica. 170 (4): 189–94. PMID 3888708.
Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F (1985). "The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial". Dermatologica. 170 (4): 195–8. PMID 3888709.
Schmidt H, Hjorth N, Holm P (1987). "Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate". Dermatologica. 175 (3): 145–7. PMID 3653463.

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 465–. ISBN 978-1-4757-2085-3.

[pmid6370748-2] Schmidt H, Hjorth N, Holm P (1984). "A randomized trial on the D-homosteroid domoprednate (Ro 12-7024) in the treatment of dermatoses". Dermatologica. 168 (3): 127–30. PMID 6370748.

[pmid3888708-3] Serup J, Holm P (1985). "Domoprednate (Stermonid), a topical D-homocorticosteroid, skin atrophy and telangiectasia. A double-blind, randomized comparison with hydrocortisone butyrate, betamethasone valerate, clobetasole propionate and placebo". Dermatologica. 170 (4): 189–94. PMID 3888708.

[pmid3888709-4] Christiansen JV, Foged E, Holm P, Jørgensen AS, Reymann F (1985). "The treatment of psoriasis with 0.1% domoprednate (a D-homocorticosteroid) and 0.1% betamethasone valerate ointment. A double-blind, randomized trial". Dermatologica. 170 (4): 195–8. PMID 3888709.

[pmid3653463-5] Schmidt H, Hjorth N, Holm P (1987). "Domoprednate, a new nonhalogenated topical steroid: comparison to hydrocortisone butyrate". Dermatologica. 175 (3): 145–7. PMID 3653463.