Bromhexine

Bromhexine is a mucolytic drug used in the treatment of respiratory disorders associated with viscid or excessive mucus.[1]

Bromhexine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • A (Aus)
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability75-80%
Elimination half-life12 hr
Identifiers
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.020.622
Chemical and physical data
FormulaC14H20Br2N2
Molar mass376.136 g·mol−1
3D model (JSmol)
 NY (what is this?)  (verify)

It was patented in 1961 and came into medical use in 1966.[2]

Function

Bromhexine is intended to support the body's mechanisms for clearing mucus from the respiratory tract. It is secretolytic, increasing the production of serous mucus in the respiratory tract, which makes the phlegm thinner and less viscous. This contributes to a secretomotoric effect, allowing the cilia to more easily transport the phlegm out of the lungs. For this reason it is often added to cough syrups.

Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as "secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport".

Bromhexine is contained in various formulations, high and low strength syrups 8 mg/5 ml, 4 mg/5 ml, tablets and soluble tablets (both with 8 mg bromhexine) and solution for oral use 10 mg/5 ml, adapted to the need of the patients. The posology varies with the age and weight, but there are products for all age groups from infant on. Bromhexine is well established and tolerated.

Brand names
  • Broncholyte Elixir
  • Bisolvon
  • Paxirasol
  • Barkacin
  • Bromhexin
  • Vasican
  • Bisolex
  • Robitussin Chesty/Forte
  • Duro-Tuss Chesty/Forte
  • Benadryl Chesty/Forte
  • Movex
  • Bromex
  • Solvex
  • Mucolyte
  • Brofentol
  • Brofentol Plus
  • Dysolvon
  • Flegamina
  • Ventilate Forte (combination of bromhexine and salbutamol)
  • Cofdex

References
  1. Morton, Ian; Hall, Judith (1999). Concise Dictionary of Pharmacological Agents. Springer. p. 55. ISBN 0-7514-0499-3. Retrieved 2009-06-03.
  2. Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 544. ISBN 9783527607495.
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