US Zika Pregnancy Registry

Eligibility for the Registry

• Pregnant women and infants who meet the following criteria are eligible for the US Zika Pregnancy Registry: Pregnant women in the United States* with laboratory evidence of Zika virus infection (positive or equivocal test results, regardless of whether they have symptoms) and periconceptionally, prenatally or perinatally exposed infants born to these women.
• Infants with laboratory evidence of congenital Zika virus infection (positive or equivocal test results, regardless of whether they have symptoms) and their mothers.

*Includes the 50 US states, the District of Columbia, and the following jurisdictions:  American Samoa, Federated States of Micronesia, Guam, Northern Mariana Islands, and Republic of the Marshall Islands, Republic of Palau, and US Virgin Islands. Pregnant women in Puerto Rico are excluded from the Registry and are followed by the Zika Active Pregnancy Surveillance System (ZAPSS), a similar system specifically tailored to Puerto Rico.

Health Departments: How to Participate

State, tribal, local, and territorial health departments can participate in the US Zika Pregnancy Registry. They can

• Identify pregnant women and infants eligible for Zika virus testing in accordance with state or CDC guidelines.
• Coordinate testing at a state public health laboratory or CDC for those eligible.
• Report information about pregnant women in the United States with laboratory evidence of Zika virus infection (positive or equivocal test results, regardless of whether they have symptoms) and information about periconceptionally, prenatally or perinatally exposed infants born to these women, including infants with congenital Zika virus infection
• Collect enhanced surveillance data about pregnant women and their infants who are eligible for the Registry.
• Work with CDC to determine state-specific methods for collecting and sharing data.

Healthcare Providers: How to Participate

CDC and state, tribal, local, and territorial health departments request that healthcare providers participate in the US Zika Pregnancy Registry.

Obstetric healthcare providers can:

• Report information about pregnant women with laboratory evidence of Zika virus to their state, tribal, local, or territorial health department.
• Collect pertinent clinical information about pregnant women and their infants on the Pregnancy and Zika Virus Disease Surveillance forms.
• Provide the information to state, tribal, local or territorial health departments or directly to CDC registry staff if asked to do so by local health officials.
• Notify state, tribal, local, or territorial health department staff or CDC registry staff of adverse events (e.g., spontaneous abortion, termination of pregnancy).

Pediatric healthcare providers can:

• Identify and report suspected congenital Zika virus exposure to their state, tribal, local, or territorial health department for possible testing.
• Collect pertinent clinical information about infants born to women with laboratory evidence of Zika virus infection or infants with congenital Zika virus infection.
• Provide the information to state, tribal, local or territorial health departments or directly to CDC registry staff if asked to do so by local health officials.
• Notify state, tribal, local, or territorial health department staff or CDC registry staff of adverse events (e.g., perinatal or infant deaths).

Healthcare providers practicing in Puerto Rico should report information to the Puerto Rico Zika Active Pregnancy Surveillance System (ZAPSS) rather than to the US Zika Pregnancy Registry.