Thrombophlebitis is a phlebitis (inflammation of a vein) related to a thrombus (blood clot).[2] When it occurs repeatedly in different locations, it is known as thrombophlebitis migrans (migrating thrombophlebitis).

Other namesPhlebitis[1]
Ultrasonographic image showing thrombosis of the great saphenous vein.
Risk factorsSmoking, Lupus[1]
Diagnostic methodDoppler ultrasound, Venography[1]
TreatmentBlood thinners, Pain medication[1]

Signs and symptoms

The following symptoms or signs are often associated with thrombophlebitis, although thrombophlebitis is not restricted to the veins of the legs.[1][3]


In terms of complications, one of the most serious occurs when the superficial blood clot is associated with a deeper venous thrombosis; this can then dislodge, traveling through the heart and occluding the dense capillary network of the lungs This is a pulmonary embolism which can be life-threatening to the affected individual.[4]


Deep vein thrombosis/ right leg

Thrombophlebitis causes include disorders related to increased tendency for blood clotting and reduced speed of blood in the veins such as prolonged immobility; prolonged traveling (sitting) may promote a blood clot leading to thrombophlebitis but this occurs relatively less. High estrogen states such as pregnancy, estrogen replacement therapy, or oral contraceptives are associated with an increased risk of thrombophlebitis.[1][3][5]

Specific disorders associated with thrombophlebitis include superficial thrombophlebitis which affects veins near the skin surface, deep venous thrombosis which affects deeper veins, and pulmonary embolism.[6]

Those with familial clotting disorders such as protein S deficiency, protein C deficiency, or factor V Leiden are also at increased risk of thrombophlebitis. Thrombophlebitis can be found in people with vasculitis including Behçet's disease. Thrombophlebitis migrans can be a sign of malignancy – Trousseau sign of malignancy.[7]


The diagnosis for thrombophlebitis is primarily based on the appearance of the affected area. Frequent checks of the pulse, blood pressure, and temperature may be required. If the cause is not readily identifiable, tests may be performed to determine the cause, including the following:[1][3]


Prevention consists of walking, drinking fluids and if currently hospitalized, changing of IV lines.[1] Walking is especially suggested after a long period seated, particularly when one travels.[8]


Ibuprofen (NSAID)

In terms of treatment for this condition the individual may be advised to do the following: raise the affected area to decrease swelling, and relieve pressure off of the affected area so it will encounter less pain. In certain circumstances drainage of the clot might be an option. In general, treatment may include the following:[1][3][4]


Thrombophlebitis occurs almost equally between women and men, though males do have a slightly higher possibility. The average age of developing thrombophlebitis, based on analyzed incidents, is 54 for men and 58 for women.[4]

See also


  1. "Thrombophlebitis: MedlinePlus Medical Encyclopedia". Retrieved 23 September 2016.
  2. Torpy JM, Burke AE, Glass RM (July 2006). "JAMA patient page. Thrombophlebitis". JAMA. 296 (4): 468. doi:10.1001/jama.296.4.468. PMID 16868304.
  3. "Thrombophlebitis Clinical Presentation: History, Physical Examination, Causes". Retrieved 23 October 2016.
  4. Raval, P. (1 January 2014). Thrombophlebitis☆. Reference Module in Biomedical Sciences. doi:10.1016/B978-0-12-801238-3.05368-X. ISBN 9780128012383.
  5. Philbrick, John T.; Shumate, Rebecca; Siadaty, Mir S.; Becker, Daniel M. (23 October 2016). "Air Travel and Venous Thromboembolism: A Systematic Review". Journal of General Internal Medicine. 22 (1): 107–114. doi:10.1007/s11606-006-0016-0. ISSN 0884-8734. PMC 1824715. PMID 17351849.
  6. "Superficial Thrombophlebitis: Background, Pathophysiology, Etiology". eMedicine. Medscape. 12 July 2016. Retrieved 23 October 2016.
  7. Varki, Ajit (15 September 2007). "Trousseau's syndrome: multiple definitions and multiple mechanisms". Blood. 110 (6): 1723–1729. doi:10.1182/blood-2006-10-053736. ISSN 0006-4971. PMC 1976377. PMID 17496204.
  8. Tamparo, Carol D. (2016). Diseases of the Human Body. F.A. Davis. p. 292. ISBN 9780803657915. Retrieved 23 October 2016.

Further reading

External resources
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