Simfibrate

Simfibrate
Clinical data
Trade names	Cholesolvin
Other names	3-{[2-(4-Chlorophenoxy)-2-methylpropanoyl]oxy}propyl 2-(4-chlorophenoxy)-2-methylpropanoate
ATC code	C10AB06 (WHO) ;
Identifiers
	IUPAC name Propane-1,3-diyl bis[2-(4-chlorophenoxy)-2-methylpropanoate];
CAS Number	14929-11-4;
PubChem CID	5217;
ChemSpider	5028 ;
UNII	L2R75RQX26;
KEGG	D01212 ;
CompTox Dashboard (EPA)	DTXSID8057647 ;
ECHA InfoCard	100.035.438
Chemical and physical data
Formula	C23H26Cl2O6
Molar mass	469.36 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc2ccc(OC(C(=O)OCCCOC(=O)C(Oc1ccc(Cl)cc1)(C)C)(C)C)cc2;
	InChI InChI=1S/C23H26Cl2O6/c1-22(2,30-18-10-6-16(24)7-11-18)20(26)28-14-5-15-29-21(27)23(3,4)31-19-12-8-17(25)9-13-19/h6-13H,5,14-15H2,1-4H3 ; Key:JLRNKCZRCMIVKA-UHFFFAOYSA-N ;
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Simfibrate (JAN/INN; trade name Cholesolvin) is a fibrate that has been used for the treatment of hyperlipidemia.[1][2]

References

Verma, Niharika (2016). "Introduction to Hyperlipidemia and its Treatment: A Review". International Journal of Current Pharmaceutical Research. 9: 6. doi:10.22159/ijcpr.2017v9i1.16616.
Olsson, Anders G.; Orö, Lars; Rössner, Stephan (1974). "Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate". Atherosclerosis. 19 (3): 407–415. doi:10.1016/S0021-9150(74)80005-5. PMID 4364073.

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[1] Verma, Niharika (2016). "Introduction to Hyperlipidemia and its Treatment: A Review". International Journal of Current Pharmaceutical Research. 9: 6. doi:10.22159/ijcpr.2017v9i1.16616.

[2] Olsson, Anders G.; Orö, Lars; Rössner, Stephan (1974). "Clinical and metabolic effects of pentaerythritol tetranicotinate in combination with cholesolvin or clofibrate". Atherosclerosis. 19 (3): 407–415. doi:10.1016/S0021-9150(74)80005-5. PMID 4364073.

PPAR modulators
PPARα	Agonists: 15-HETE 15-HpETE Aleglitazar Aluminium clofibrate Arachidonic acid Bezafibrate Clofibrate CP-775146 Daidzein DHEA (prasterone) (in rodents) Elafibranor Etomoxir Fenofibrate Genistein Gemfibrozil GW-7647 Lanifibranor Leukotriene B₄ LG-101506 LG-100754 Lobeglitazone Muraglitazar Oleylethanolamide Palmitoylethanolamide Pemafibrate Perfluorononanoic acid Perfluorooctanoic acid Pioglitazone Saroglitazar Sodelglitazar Tesaglitazar Tetradecylthioacetic acid Troglitazone WY-14643 Antagonists: GW-6471 MK-886
PPARδ	Agonists: 15-HETE 15-HpETE Arachidonic acid Bezafibrate Daidzein Elafibranor Fonadelpar Genistein GW-0742 GW-501516 L-165,041 Lanifibranor LG-101506 Seladelpar Sodelglitazar Tetradecylthioacetic acid Antagonists: FH-535 GSK-0660 GSK-3787
PPARγ	Agonists: 5-Oxo-ETE 5-Oxo-15-hydroxy-ETE 15-Deoxy-Δ^12,14-prostaglandin J₂ 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Ciglitazone Daidzein Darglitazone Edaglitazone Efatutazone Englitazone Etalocib Farglitazar Genistein GW-1929 Ibuprofen Imiglitazar Indeglitazar Lanifibranor LG-100268 LG-100754 LG-101506 Lobeglitazone Muraglitazar (muroglitazar) nTZDpa Naveglitazar Netoglitazone Oxeglitazar Peliglitazar Pemaglitazar Perfluorononanoic acid Pioglitazone Prostaglandin J₂ Ragaglitazar Reglitazar Rivoglitazone Rosiglitazone RS5444 Saroglitazar Sipoglitazar Sodelglitazar Telmisartan Tesaglitazar Troglitazone SPPARMs: BADGE EPI-001 INT-131 MK-0533 S26948 Antagonists: FH-535 GW-9662 SR-202 T-0070907 Unknown: SR-1664
Non-selective	Agonists: Ciprofibrate Clinofibrate Clofibride Englitazone Etofibrate Farglitazar Netoglitazone Ronifibrate Rivoglitazone Simfibrate
See also Receptor/signaling modulators Nuclear receptor modulators