GW0742

GW0742
Clinical data
ATC code	None;
Legal status
Legal status	Investigational;
Identifiers
	IUPAC name [4-[[[2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methyl phenoxy]-acetic acid[1];
CAS Number	317318-84-6;
PubChem CID	9934458;
IUPHAR/BPS	2686;
ChemSpider	8110086;
KEGG	C15625;
ChEMBL	ChEMBL38508;
CompTox Dashboard (EPA)	DTXSID9040760 ;
Chemical and physical data
Formula	C21H17F4NO3S2
Molar mass	471.488 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c3c(F)cc(c1nc(c(s1)CSc2cc(c(OCC(=O)O)cc2)C)C)cc3;
	InChI InChI=InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28); Key:HWVNEWGKWRGSRK-UHFFFAOYSA-N;

GW0742 (also known as GW610742) is a PPARδ/β agonist[2][3][4] that is investigated for drug use by GlaxoSmithKline.[5]

References

"Cayman Chemical GW0742". Retrieved 31 Mar 2013.
Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor β Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.
Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.
Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.
Wagner, N.; Jehl-Pietri, C.; Lopez, P.; Murdaca, J.; Giordano, C.; Schwartz, C.; Gounon, P.; Hatem, S. N.; Grimaldi, P.; Wagner, K.-D. (2009). "Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin" (PDF). Cardiovascular Research. 83 (1): 61–71. doi:10.1093/cvr/cvp106. PMID 19351742.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[1] "Cayman Chemical GW0742". Retrieved 31 Mar 2013.

[2] Smith, S. A.; Monteith, G. R.; Robinson, J. A.; Venkata, N. G.; May, F. J.; Roberts-Thomson, S. J. (2004). "Effect of the peroxisome proliferator-activated receptor β Activator GW0742 in rat cultured cerebellar granule neurons". Journal of Neuroscience Research. 77 (2): 240–249. doi:10.1002/jnr.20153. PMID 15211590.

[3] Haskova, Z.; Hoang, B.; Luo, G.; Morgan, L. A.; Billin, A. N.; Barone, F. C.; Shearer, B. G.; Barton, M. E.; Kilgore, K. S. (2008). "Modulation of LPS-induced pulmonary neutrophil infiltration and cytokine production by the selective PPARβ/δ ligand GW0742". Inflammation Research. 57 (7): 314–321. doi:10.1007/s00011-007-7157-4. PMID 18622687.

[4] Sznaidman, M. L.; Haffner, C. D.; Maloney, P. R.; Fivush, A.; Chao, E.; Goreham, D.; Sierra, M. L.; Legrumelec, C.; Xu, H. E.; Montana, V. G.; Lambert, M. H.; Willson, T. M.; Oliver, W. R.; Sternbach, D. D. (2003). "Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ)—synthesis and biological activity". Bioorganic & Medicinal Chemistry Letters. 13 (9): 1517. doi:10.1016/S0960-894X(03)00207-5.

[5] Wagner, N.; Jehl-Pietri, C.; Lopez, P.; Murdaca, J.; Giordano, C.; Schwartz, C.; Gounon, P.; Hatem, S. N.; Grimaldi, P.; Wagner, K.-D. (2009). "Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin" (PDF). Cardiovascular Research. 83 (1): 61–71. doi:10.1093/cvr/cvp106. PMID 19351742.

PPAR modulators
PPARα	Agonists: 15-HETE 15-HpETE Aleglitazar Aluminium clofibrate Arachidonic acid Bezafibrate Clofibrate CP-775146 Daidzein DHEA (prasterone) (in rodents) Elafibranor Etomoxir Fenofibrate Genistein Gemfibrozil GW-7647 Lanifibranor Leukotriene B₄ LG-101506 LG-100754 Lobeglitazone Muraglitazar Oleylethanolamide Palmitoylethanolamide Pemafibrate Perfluorononanoic acid Perfluorooctanoic acid Pioglitazone Saroglitazar Sodelglitazar Tesaglitazar Tetradecylthioacetic acid Troglitazone WY-14643 Antagonists: GW-6471 MK-886
PPARδ	Agonists: 15-HETE 15-HpETE Arachidonic acid Bezafibrate Daidzein Elafibranor Fonadelpar Genistein GW-0742 GW-501516 L-165,041 Lanifibranor LG-101506 Seladelpar Sodelglitazar Tetradecylthioacetic acid Antagonists: FH-535 GSK-0660 GSK-3787
PPARγ	Agonists: 5-Oxo-ETE 5-Oxo-15-hydroxy-ETE 15-Deoxy-Δ^12,14-prostaglandin J₂ 15-HETE 15-HpETE Aleglitazar Arachidonic acid Balaglitazone Berberine Bezafibrate Cannabidiol Cevoglitazar Ciglitazone Daidzein Darglitazone Edaglitazone Efatutazone Englitazone Etalocib Farglitazar Genistein GW-1929 Ibuprofen Imiglitazar Indeglitazar Lanifibranor LG-100268 LG-100754 LG-101506 Lobeglitazone Muraglitazar (muroglitazar) nTZDpa Naveglitazar Netoglitazone Oxeglitazar Peliglitazar Pemaglitazar Perfluorononanoic acid Pioglitazone Prostaglandin J₂ Ragaglitazar Reglitazar Rivoglitazone Rosiglitazone RS5444 Saroglitazar Sipoglitazar Sodelglitazar Telmisartan Tesaglitazar Troglitazone SPPARMs: BADGE EPI-001 INT-131 MK-0533 S26948 Antagonists: FH-535 GW-9662 SR-202 T-0070907 Unknown: SR-1664
Non-selective	Agonists: Ciprofibrate Clinofibrate Clofibride Englitazone Etofibrate Farglitazar Netoglitazone Ronifibrate Rivoglitazone Simfibrate
See also Receptor/signaling modulators Nuclear receptor modulators

GW0742

See also

References