Interleukin 30

IL27
Identifiers
Aliases	IL27, IL-27, IL-27A, IL27A, IL27p28, IL30, p28, Interleukin 30, IL-30, interleukin 27
External IDs	OMIM: 608273 MGI: 2384409 HomoloGene: 17087 GeneCards: IL27
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	28,512,051 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	126,594,941 bp[2]
Gene ontology
Molecular function	• cytokine activity; • interleukin-27 receptor binding; • receptor binding; • protein binding;
Cellular component	• extracellular region; • extracellular space; • endoplasmic reticulum lumen; • cytosol;
Biological process	• innate immune system; • inflammatory response; • regulation of T-helper 1 cell differentiation; • regulation of defense response to virus; • response to bacterium; • immune system process; • positive regulation of interferon-gamma biosynthetic process; • regulation of T cell proliferation; • positive regulation of defense response to virus by host; • regulation of receptor activity; • interleukin-27-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	246778
	246779
	ENSG00000197272
	ENSMUSG00000044701
	Q8NEV9
	Q8K3I6
	NM_145659
	NM_145636
	NP_663634
	NP_663611
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin-30 (IL-30) is a protein with a molecular weight of 28 kilodaltons, which forms one chain of the heterodimeric cytokine called interleukin 27 (IL-27), thus is sometimes called IL27-p28. The other chain of IL-27 is a molecule called Epstein-Barr induced gene-3 (EBI3). IL-30 is a member of the long-chain, 4-helix bundle family of cytokines, making it structurally similar to IL-6.[5] This gene for this molecule is now officially called IL-27 under HGNC guidelines.[6]

References

GRCh38: Ensembl release 89: ENSG00000197272 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000044701 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.
http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197272 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044701 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12121660-5] Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, Hibbert L, Churakova T, Travis M, Vaisberg E, Blumenschein WM, Mattson JD, Wagner JL, To W, Zurawski S, McClanahan TK, Gorman DM, Bazan JF, de Waal Malefyt R, Rennick D, Kastelein RA (June 2002). "IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells". Immunity. 16 (6): 779–90. doi:10.1016/S1074-7613(02)00324-2. PMID 12121660.

[6] ttp://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=19157