Interleukin 32

IL32
Identifiers
Aliases	IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd, Interleukin 32, IL-32
External IDs	OMIM: 606001 HomoloGene: 128400 GeneCards: IL32
Gene location (Human)
Chr.	Chromosome 16 (human)[1]
End	3,082,192 bp[1]
Gene ontology
Molecular function	• cytokine activity; • protein binding;
Cellular component	• extracellular region; • membrane; • cytosol; • extracellular space;
Biological process	• defense response; • cell adhesion; • immune response; • regulation of receptor activity; • cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9235
	n/a
	ENSG00000008517
	n/a
	P24001
	n/a
NM_001012631; NM_001012632; NM_001012633; NM_001012634; NM_001012635;
	NM_001012636; NM_001012718; NM_001308078; NM_004221
	n/a
NP_001012649; NP_001012650; NP_001012651; NP_001012652; NP_001012653;
	NP_001012654; NP_001012736; NP_001295007; NP_004212; NP_001356516; NP_001356517; NP_001356518; NP_001356519; NP_001356520; NP_001356521; NP_001356522; NP_001356524; NP_001356525
	n/a
	Wikidata
View/Edit Human

Interleukin 32 (Il32) is a protein that in humans is encoded by the IL32 gene.[3]

Function

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2.[4]

IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.[5]

References

GRCh38: Ensembl release 89: ENSG00000008517 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Interleukin 32".
Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (January 2005). "Interleukin-32: a cytokine and inducer of TNFalpha". Immunity. 22 (1): 131–42. doi:10.1016/j.immuni.2004.12.003. PMID 15664165.
Mabilleau G, Sabokbar A (2009). "Interleukin-32 promotes osteoclast differentiation but not osteoclast activation". PLoS ONE. 4 (1): e4173. doi:10.1371/journal.pone.0004173. PMC 2613539. PMID 19137064.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000008517 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Interleukin 32".

[pmid15664165-4] Kim SH, Han SY, Azam T, Yoon DY, Dinarello CA (January 2005). "Interleukin-32: a cytokine and inducer of TNFalpha". Immunity. 22 (1): 131–42. doi:10.1016/j.immuni.2004.12.003. PMID 15664165.

[pmid19137064-5] Mabilleau G, Sabokbar A (2009). "Interleukin-32 promotes osteoclast differentiation but not osteoclast activation". PLoS ONE. 4 (1): e4173. doi:10.1371/journal.pone.0004173. PMC 2613539. PMID 19137064.