Elsilimomab

Elsilimomab
Monoclonal antibody
Type	Whole antibody
Source	Mouse
Target	IL-6
Clinical data
ATC code	none;
Identifiers
CAS Number	468715-71-1 ;
ChemSpider	none;
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Elsilimomab (also known as B-E8) is a mouse monoclonal antibody[1] and an immunosuppressive drug. B-E8 was developed by Diaclone[2], a French company which produces many mouse monoclonal antibodies.

It (OPR-003) targets (and blocks) Interleukin-6.[3]

It has undergone a number of early stage clinical trails, e.g. for lymphoma and myeloma.[4]

It was used as a template to develop a high-affinity, antagonist, fully human anti-IL-6 mAb 1339.[4]

References

"WHO Drug Information" (PDF). p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer
"Datasheet B-E8 mAb on Diaclone website".
"First Fully Human Anti-IL6 Antibody Under Development". Oct 2006.
Fulciniti, M; Hideshima, T; Vermot-Desroches, C; Pozzi, S; Nanjappa, P; Shen, Z; Patel, N; Smith, ES; et al. (2009). "A high-affinity fully human anti-IL-6 mAb (OP-R003-1, 1339) for the treatment of Multiple Myeloma". Clinical Cancer Research. 15 (23): 7144–52. doi:10.1158/1078-0432.CCR-09-1483. PMC 2787636. PMID 19934301.

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[1] "WHO Drug Information" (PDF). p11:immunoglobulin G1, anti-(human interleukin 6) (mouse monoclonal B-E8 heavy chain), disulfide with mouse monoclonal B-E8 k-chain, dimer

[2] "Datasheet B-E8 mAb on Diaclone website".

[3] "First Fully Human Anti-IL6 Antibody Under Development". Oct 2006.

[F2009-4] Fulciniti, M; Hideshima, T; Vermot-Desroches, C; Pozzi, S; Nanjappa, P; Shen, Z; Patel, N; Smith, ES; et al. (2009). "A high-affinity fully human anti-IL-6 mAb (OP-R003-1, 1339) for the treatment of Multiple Myeloma". Clinical Cancer Research. 15 (23): 7144–52. doi:10.1158/1078-0432.CCR-09-1483. PMC 2787636. PMID 19934301.