Mavrilimumab

Mavrilimumab is a human monoclonal antibody[1] that inhibits human granulocyte macrophage colony-stimulating factor receptor (GM-CSF-R).[2]

Mavrilimumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetGM-CSF receptor alpha chain
Clinical data
ATC code
  • none
Identifiers
CAS Number
IUPHAR/BPS
ChemSpider
  • none
UNII
Chemical and physical data
FormulaC6706H10438N1762O2104S54
Molar mass143.2 kg/mol g·mol−1
 NY (what is this?)  (verify)

Mavrilimumab was discovered as CAM-3001 by Cambridge Antibody Technology and is being developed by MedImmune, Inc.[3] as an investigational drug for the treatment of rheumatoid arthritis

Mavrilimumab has been studied in a phase 1 dose-ranging trial[2] and a phase 2a clinical trial, both sponsored by Medimmune.[4] The phase 2a trial, which studied mavrilimumab doses of up to 100 mg, reported that 55.7% of subjects met the primary endpoint of a ≥1.2 decrease from baseline in disease activity scores at week 12 (vs. only 34.7% of placebo subjects).[4]

As of 2013, two further clinical studies were reported to be underway in rheumatoid arthritis patients to investigate these effects further.[5]

In early 2017 the phase IIb study was reported to be showing promising results.[6]

References
  1. "Statement On A Nonproprietary Name Adopted By The USAN Council: Mavrilimumab" (PDF). American Medical Association.
  2. Gerd R Burmester; Eugen Feist; Matthew A Sleeman; Bing Wang; Barbara White; Fabio Magrini (1 September 2011). "Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study". Ann. Rheum. Dis. 70 (9): 1542–1549. doi:10.1136/ard.2010.146225. PMC 3147227. PMID 21613310.
  3. "Archived copy" (PDF). Archived from the original (PDF) on 2012-09-28. Retrieved 2011-09-08.CS1 maint: archived copy as title (link)
  4. Gerd R Burmester; Michael E Weinblatt; Iain B McInnes; Duncan Porter; Olga Barbarash; Mykola Vatutin; Istvan Szombati; Ehsanollah Esfandiari; Matthew A Sleeman; Christopher D Kane; Guy Cavet; Bing Wang; Alex Godwood; Fabio Magrini & the EARTH Study Group (2013). "Efficacy and safety of mavrilimumab in subjects with rheumatoid arthritis". Ann Rheum Dis. 72 (9): 1445–1452. doi:10.1136/annrheumdis-2012-202450. PMC 3756523. PMID 23234647.
  5. Manuela Di Franco; Maria Chiara Gerardi; Bruno Lucchino & Fabrizio Conti (12 March 2014). "Mavrilimumab: an evidence based review of its potential in the treatment of rheumatoid arthritis". Core Evidence. 9: 41–48. doi:10.2147/CE.S39770. PMC 3958547. PMID 24648832.
  6. Agent that Targets GM-CSF Shows Promise in RA - Novel monoclonal antibody was rapidly effective in mild-to-moderate disease. Feb 2017


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