Avanafil
Avanafil is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012[1] and by EMA on June 21, 2013.[2] Avanafil is known by the trademark names Stendra and Spedra. It was invented at Mitsubishi Tanabe Pharma, formerly known as Tanabe Seiyaku Co.,[3] and licensed to Vivus Inc., which partnered with Menarini Group to commercialise Spedra in over forty European countries, Australia, and New Zealand.[4] Metuchen Pharmaceuticals obtained exclusive rights within the United States.[5]
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![]() Avanafil is a PDE5 inhibitor | |
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Trade names | Stendra |
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Routes of administration | Oral |
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Formula | C23H26ClN7O3 |
Molar mass | 483.951 g/mol g·mol−1 |
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Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme found in various body tissues, primarily in the corpus cavernosum penis.[6] Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum serum concentration in about thirty to forty-five minutes.[7] About two-thirds of the participants were able to engage in sexual activity within fifteen minutes.[7]
See also
- Tadalafil (Cialis)
- Vardenafil (Levitra/Staxyn)
- Sildenafil (Viagra)
References
- "FDA approves Stendra for erectile dysfunction" (Press release). Food and Drug Administration (FDA). April 27, 2012.
- "Spedra (avanafil)". European Medicines Agency. Retrieved 17 April 2014.
- https://patents.google.com/patent/US6656935B2
- "Archived copy". Archived from the original on 2015-12-08. Retrieved 2013-07-26.CS1 maint: archived copy as title (link)
- http://ir.vivus.com/news-releases/news-release-details/vivus-and-metuchen-pharmaceuticals-announce-license-agreement
- "avanafil, Spedra". Medicine Net. Retrieved 17 April 2014.
- Kyle, Jeffery; Brown, Dana (2013). "Avanafil for Erectile Dysfunction" (PDF). Annals of Pharmacotherapy. Sage Publishing. doi:10.1177/1060028013501989. Retrieved 28 September 2013.
- Yamada, K.; Matsuki, K.; Omori, K.; Kikkawa, K.; 2004, U.S. Patent 6,797,709
External links
- Faster-Working Erectile Dysfunction Drug?. CBS News. November 24, 2009.
- Vivus says men taking avanafil were more likely to be ready for sex within 15 minutes. The Gaea Times. January 11, 2010.