Enoximone
Enoximone (INN, trade name Perfan) is an imidazole phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure and is selective for phosphodiesterase 3.[1]
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| Trade names | Perfan |
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| Routes of administration | Intravenous |
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| Bioavailability | 50% (oral) |
| Protein binding | 85% |
| Metabolism | Liver (oxidation) |
| Elimination half-life | 4 to 10 hours |
| Excretion | Renal (60 to 70%) |
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| Chemical and physical data | |
| Formula | C12H12N2O2S |
| Molar mass | 248.302 g/mol g·mol−1 |
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| Melting point | 255 to 258 °C (491 to 496 °F) (decomposes) |
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Synthesis
Prepn: BE 883856 (1980 to Richardson-Merrell); R. A. Schnettler et al., U.S. Patent 4,405,635 (1983 to Merrell-Dow)
References
- Boldt J, Suttner S (September 2007). "Combined use of ultra-short acting beta-blocker esmolol and intravenous phosphodiesterase 3 inhibitor enoximone". Expert Opin Pharmacother. 8 (13): 2135–47. doi:10.1517/14656566.8.13.2135. PMID 17714066.
- Schnettler, Richard A.; Dage, Richard C.; Grisar, J. Martin (1982). "4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents". Journal of Medicinal Chemistry. 25 (12): 1477–1481. doi:10.1021/jm00354a017. ISSN 0022-2623.
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