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Reported Tuberculosis in the United States, 2013

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Table 22: Epidemiologic Characteristics of Cases in GENType Clusters1 by Alert Levels Based on Log-likelihood Ratios (LLR)2: United States, 2011–2013

Case Characteristics Unique Alert Levels for Clustered Cases3
Clustered Non-alerted
(LLR <5)
Medium (LLR 5 – <10) High (LLR ≥10)
No. (%) No. (%) No. (%) No. (%) No. (%)
Total 17,077 (78.7) 4,625 (21.3) 2,652 (57.3) 997 (21.6) 976 (21.1)
Race and Ethnicity
Hispanic or Latino 4,746 (77.0) 1,415 (23.0) 923 (65.2) 305 (21.6) 187 (13.2)
American Indian/Alaska Native 165 (51.6) 155 (48.4) 17 (11) 31 (20.0) 107 (69.0)
Asian 5,824 (87.0) 870 (13.0) 747 (85.9) 71 (8.2) 52 (6)
Black or African American 3,205 (68.7) 1,457 (31.3) 613 (42.1) 356 (24.4) 488 (33.5)
Native Hawaiian/Other Pacific Islander 80 (54.4) 67 (45.6) 34 (50.8) 30 (44.8) 3 (4.5)
White 2,737 (81.6) 618 (18.4) 292 (47.3) 196 (31.7) 130 (21.0)
Multiple Race 287 (89.7) 33 (10.3) 22 (66.7) 5 (15.2) 6 (18.2)
Unknown or Missing  33 (76.7) 10 (23.3) 4 (40.0) 3 (30.0) 3 (30.0)
Age Group (Years)
0–4 80 (35.1) 148 (64.9) 74 (50.0) 44 (29.7) 30 (20.3)
5–14 113 (57.7) 83 (42.3) 47 (56.6) 15 (18.1) 21 (25.3)
15–24 1,617 (71.6) 642 (28.4) 378 (58.9) 139 (21.7) 125 (19.5)
25–44 5,454 (78.9) 1,462 (21.1) 839 (57.4) 318 (21.8) 305 (20.9)
45–64 5,152 (75.3) 1,687 (24.7) 892 (52.9) 375 (22.2) 460 (24.9)
≥65 4,658 (88.5) 603 (11.5) 422 (70.0) 106 (17.6) 75 (12.4)
Unknown 3 (100.0) 0 (0.0) 0 0.0 0 (0) 0 0.0
Origin of Birth
U.S-born 5,008 (65.3) 2,661 (34.7) 1,130 (42.5) 710 (26.7) 821 (30.9)
Foreign-born 12,056 (86.1) 1,952 (13.9) 1,516 (77.7) 285 (14.6) 151 (7.7)
Unknown or Misssing 13 (52.0) 12 (48.0) 6 (50.0) 2 (16.7) 4 (33.3)
Disease Site
Pulmonary Only 12,147 (76.7) 3,698 (23.3) 2,093 (56.6) 807 (21.8) 798 (21.6)
Extrapulmonary 3,033 (86.9) 457 (13.1) 287 (62.8) 91 (19.9) 79 (17.3)
Both 1,886 (80.1) 468 (19.9) 272 (58.1) 99 (21.2) 97 (20.7)
Unknown 11 (84.6) 2 (15.4) 0 0.0 0 0.0 2 (100.0)
Sputum Smear
Positive 7,836 (75.8) 2,504 (24.2) 1,390 (55.5) 574 (22.9) 540 (21.6)
Negative 6,898 (80.8) 1,637 (19.2) 992 (60.6) 306 (18.7) 339 (20.7)
Not Done 2,321 (82.8) 482 (17.2) 270 (56.0) 117 (24.3) 95 (19.7)
Unknown or Missing 22 (91.7) 2 (8.3) 0 (0.0) 0 0.0 2 (100.0)
Cavitary disease
Yes 178 (75.4) 58 (24.6) 22 (37.9) 20 (34.5) 16 (27.6)
No 1,348 (79.6) 346 (20.4) 213 (61.6) 63 (18.2) 70 (20.2)
Unknown or Missing 360 (84.9) 64 (15.1) 37 (57.8) 16 (25) 11 (17.2)
Homeless Within Past Year
Yes 718 (56.4) 556 (43.6) 203 (36.5) 80 (14.4) 273 (49.1)
No 16,210 (80.1) 4,023 (19.9) 2,420 (60.2) 908 (22.6) 695 (17.3)
Unknown or Missing 149 (76.4) 46 (23.6) 29 (63.0) 9 (19.6) 8 (17.4)
Excess Alcohol Use Within the Past Year
Yes 1,781 (63.9) 1,005 (36.1) 396 (39.4) 248 (24.7) 361 (35.9)
No 15,026 (81.0) 3,531 (19.0) 2,202 (62.4) 736 (20.8) 593 (16.8)
Unknown or Missing 270 (75.2) 89 (24.8) 54 (60.7) 13 (14.6) 22 (24.7)
Injecting Drug Use Within Past Year
Yes 186 (59.4) 127 (40.6) 67 (52.8) 19 (15) 41 (32.3)
No 16,618 (79.0) 4,408 (21.0) 2,535 (57.5) 965 (21.9) 908 (20.6)
Unknown or Missing 273 (75.2) 90 (24.8) 50 (55.6) 13 (14.4) 27 (30)
Non-Injecting Drug Use Within Past Year
Yes 922 (55.5) 740 (44.5) 303 (40.9) 164 (22.2) 273 (36.9)
No 15,864 (80.7) 3,796 (19.3) 2,300 (60.6) 820 (21.6) 676 (17.8)
Unknown or Missing 291 (76.6) 89 (23.4) 49 (55.1) 13 (14.6) 27 (30.3)
Resident of a Correction Facility at the Time of Diagnosis
Yes 608 (720.) 236 (28.0) 120 (50.9) 51 (21.6) 65 (27.5)
No 16,406 (79.0) 4,371 (21.0) 2,523 (57.7) 944 (21.6) 904 (20.7)
Unknown or Missing 63 (77.8) 18 (22.2) 9 (50.0) 2 (11.1) 7 (38.9)
HIV Status
Positive 957 (70.7) 397 (29.3) 210 (52.9) 70 (17.6) 117 (29.5)
Negative 13,623 (78.5) 3,729 (21.5) 2,146 (57.6) 809 (21.7) 774 (20.8)
Refused 737 (86.1) 119 (13.9) 73 (61.3) 35 (29.4) 11 (9.2)
Not Offered 1,312 (81.3) 301 (18.7) 172 (57.1) 65 (21.6) 64 (21.3)
Unknown, Missing or Indeterminate 488 (85.0) 79 (15.0) 51 (64.6) 18 (22.8) 10 (12.7)
Multi-Drug Resistant TB
Yes 248 (83.2) 50 (16.8) 43 (86.0) 5 (10.0) 2 (4.0)
No 16,460 (78.6) 4,484 (21.4) 2,567 (57.3) 975 (21.7) 942 (21.0)
Unknown or Missing 369 (80.2) 91 (19.8) 42 (46.2) 17 (18.7) 32 (35.2)

1 GENType clusters have two or more cases with matching spoligotype and 24-locus locus mycobacterial interspersed repetitive unit-variable number tandem repeat type within a county during the specified 3-year time period .

2 Alert levels are based on a log-likelihood ratio (LLR), which calculates the geographic concentration of a genotype in a county compared to the rest of the country during a 3-year period.

3 There were 4,625 cases in 1,532 alerted clusters: 976 cases were in 101 (6.6%) high alert clusters; 997 cases were in 338 (22.1%) medium alert clusters and 2,652 were in 1,093 (71.3%) non-alert clusters.

Note: Case counts for race categories (American Indian or Alaska Native, Asian, Black or African American, Native Hawaiian or Other Pacific Islander, and White) are mutually exclusive and do not include persons of Hispanic ethnicity or multiple race. Multiple Race does not include persons of Hispanic ethnicity.

See Surveillance Slide #36.

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