Technetium (99mTc) tilmanocept

Technetium (99mTc) tilmanocept, trade name Lymphoseek, is a radiopharmaceutical diagnostic imaging agent approved by the U.S. Food and Drug Administration (FDA) for the imaging of lymph nodes.[1][2] It is used to locate those lymph nodes which may be draining from tumors, and assist doctors in locating those lymph nodes for removal during surgery.[3]

Technetium (99mTc) tilmanocept
Clinical data
Trade namesLymphoseek
AHFS/Drugs.comlymphoseek
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration    		Intradermal, subcutaneous
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Elimination half-life1.75 to 3.05 hours at injection site
    Identifiers
    KEGG
    Chemical and physical data
    Formula(C6H10O5)n(C19H28N4O9S99mTc)3–8(C13H24N2O5S2)12–20(C5H11NS)0–17
    Molar mass15,281–23,454 g/mol[1]

    References
    1. FDA Professional Drug Information
    2. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm343525.htm
    3. Marcinow, A. M.; Hall, N.; Byrum, E.; Teknos, T. N.; Old, M. O.; Agrawal, A. (2013). "Use of a novel receptor-targeted (CD206) radiotracer, 99mTc-tilmanocept, and SPECT/CT for sentinel lymph node detection in oral cavity squamous cell carcinoma: Initial institutional report in an ongoing phase 3 study". JAMA Otolaryngology–Head & Neck Surgery. 139 (9): 895–902. doi:10.1001/jamaoto.2013.4239. PMC 4301415. PMID 24051744.


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