Nepovirus

Nepovirus is a genus of viruses in the order Picornavirales, in the family Secoviridae, in the subfamily Comovirinae. Plants serve as natural hosts. There are currently 36 species in this genus including the type species Tobacco ringspot virus.[2][3] Nepoviruses, unlike the other two genera (Comovirus and Fabavirus) in the subfamily Comovirinae, are transmitted by nematodes.[4]

Not to be confused with Nipah virus.

Nepovirus
Virus classification
(unranked): Virus
Realm: Riboviria
Phylum: incertae sedis
Order: Picornavirales
Family: Secoviridae
Subfamily: Comovirinae
Genus: Nepovirus
Type species
Tobacco ringspot virus
Species[1]
  • Aeonium ringspot virus
  • Apricot latent ringspot virus
  • Arabis mosaic virus
  • Arracacha virus A
  • Artichoke Aegean ringspot virus
  • Artichoke Italian latent virus
  • Artichoke yellow ringspot virus
  • Beet ringspot virus
  • Blackcurrant reversion virus
  • Blueberry latent spherical virus
  • Blueberry leaf mottle virus
  • Cassava American latent virus
  • Cassava green mottle virus
  • Cherry leaf roll virus
  • Chicory yellow mottle virus
  • Cocoa necrosis virus
  • Crimson clover latent virus
  • Cycas necrotic stunt virus
  • Grapevine Anatolian ringspot virus
  • Grapevine Bulgarian latent virus
  • Grapevine chrome mosaic virus
  • Grapevine deformation virus
  • Grapevine fanleaf virus
  • Grapevine Tunisian ringspot virus
  • Hibiscus latent ringspot virus
  • Lucerne Australian latent virus
  • Melon mild mottle virus
  • Mulberry mosaic leaf roll associated virus
  • Mulberry ringspot virus
  • Myrobalan latent ringspot virus
  • Olive latent ringspot virus
  • Peach rosette mosaic virus
  • Potato black ringspot virus
  • Potato virus B
  • Potato virus U
  • Raspberry ringspot virus
  • Soybean latent spherical virus
  • Tobacco ringspot virus
  • Tomato black ring virus
  • Tomato ringspot virus

Taxonomy

Group: ssRNA(+)

[3]

Structure

Viruses in Nepovirus are non-enveloped, with icosahedral geometries, and T=pseudo3 symmetry. The diameter is around 28-30 nm. Genomes are linear and segmented, bipartite, around 23.9kb in length.[2]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
NepovirusIcosahedralPseudo T=3Non-envelopedLinearSegmented

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by penetration into the host cell. Replication follows the positive stranded RNA virus replication model. Positive stranded RNA virus transcription is the method of transcription. The virus exits the host cell by tubule-guided viral movement. Plants serve as the natural host. The virus is transmitted via a vector (nematodes, mite, and thrips). Transmission routes are vector.[2]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
NepovirusPlantsNoneViral movement; mechanical inoculationViral movementCytoplasmCytoplasmNematodes; mites; thrips

Genome

Nepoviruses are classified as type IV viruses under the Baltimore classification system, and consequently contain bipartite, linear, single stranded positive sense RNA genomes. The two genome segments are encapsulated separately into two different icosahedral particles. Each of the genome segments produces a different polypeptide, which undergoes a series of steps (i.e. proteolysis, and other post-translational modifications) in order to produce a functional protein.[4]

RNA1

The first segment (RNA1) is approximately 8,000 nucleotides in length and appears as a single copy in each B type virion. It encodes the proteins that are important in replication and is the first gene to be activated.[4]

RNA2

The second segment (RNA2) is approximately 4,000–7,000 nucleotides in length and usually appears as a single copy in each M type virion. It encodes the proteins that are important in cell-cell transmission and evasion of cellular defenses.[4]

References
  1. "Virus Taxonomy: 2018 Release" (html). International Committee on Taxonomy of Viruses (ICTV). October 2018. Retrieved 5 February 2019.
  2. "Viral Zone". ExPASy. Retrieved 15 June 2015.
  3. ICTV. "Virus Taxonomy: 2014 Release". Retrieved 15 June 2015.
  4. "Notes on Genus: Nepovirus". Retrieved 6 August 2007.
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