Bornaviridae

Borna disease was first identified in 1926 and its genome was isolated in 1990. In 1996, ICTV proposed the creation of the family Bornaviridae along with the genus Bornavirus (today Orthobornavirus).[4] The viral family is named after the city of Borna in Saxony, Germany, which is where a large number of animals were lost to the sporadic encephalopathy caused by the viral disease. [5]

Table legend: "*" denotes type species.

Orthobornavirions are enveloped, with spherical geometries and helical capsids. The diameter is around 70 to 130 nm. Genomes are linear, around 8.9 kb in length. The genome codes for 9 proteins. [2]

Below are a few of the essential proteins of orthobornaviruses that have been characterized.

In the Mononegavirales order, Bornaviridae is one of only two families with viruses that replicate in the nucleus. Entry into the host cell is achieved by attachment of the viral GP glycoproteins to host receptors, which mediates clathrin-mediated endocytosis. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering, with some alternative splicing mechanism, is the method of transcription. The virus exits the host cell by nuclear pore export. This virus usually has a highly variable incubation period of around a few weeks to several months.[7] Horses, sheep, cattle, rodents, birds, and humans serve as the natural hosts. Transmission routes are fomites, contact, urine, feces, and saliva.[2]

Between 2011 and 2013, three German breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. Genomic analysis found a previously unknown orthobornavirus in a contact squirrel and in brain tissue from the three men, the researchers reported, and it is the "likely causative agent" in their deaths. Prior to this, bornaviruses were not thought to be responsible for human diseases.[9][10] More VSBV-1 infected squirrels from the subfamilies Sciurinae and Callosciurinae were also confirmed to be present not only in Germany but in the Netherlands. Zero VSBV-1 positive squirrels showed clinical signs of infection.[11] Since behavioral disease has been studied in BoDV-1 infected animals like rhesus monkeys, tree shrews, and rats, BoDV-1 has also been hypothesized to be associated with humans psychiatric conditions such as schizophrenia and affective psychoses. In several studies with large sample sizes, there has been an association with increased presence of BoDV-1 antibodies in hospitalized psychiatric patients and a higher seroprevalence rate among the psychiatric patients when compared to the control groups.[1]

• Viralzone: Bornaviridae
• Bornavirus/host Interactome
• ICTV
• Borna: Bornaviridae