Nacolomab tafenatox
Nacolomab tafenatox is a mouse monoclonal antibody[1] designed for the treatment of colorectal cancer. The antibody itself, nacolomab, is fused with enterotoxin A from Staphylococcus aureus (which is reflected by 'tafenatox' in the drug's name).[1]
Schematic image of nacolomab tafenatox.
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)
VH, VL: variable (antigen binding) domains of antibody fragment
CH1, CL: constant domains of antibody fragment
SAg: enterotoxin A (acting as a superantigen)
| Monoclonal antibody | |
|---|---|
| Type | Fab fragment |
| Source | Mouse |
| Target | colorectal tumor antigen C242 |
| Clinical data | |
| ATC code |
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| Identifiers | |
| CAS Number | |
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See also
- Naptumomab estafenatox, a drug with a similar chemical structure and mechanism
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