Adecatumumab

Adecatumumab
Monoclonal antibody
Type	Whole antibody
Source	Human
Target	EpCAM
Clinical data
ATC code	none;
Identifiers
CAS Number	503605-66-1 ;
ChemSpider	none;
Chemical and physical data
Formula	C6552H10080N1740O2052S46
Molar mass	147.5 kg/mol g·mol−1
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Adecatumumab (MT201) is a recombinant human IgG1 monoclonal antibody which is used to target tumor cells. It binds to the epithelial cell adhesion molecule (EpCAM - CD326), with the intent to trigger antibody-dependent cellular cytotoxicity. It was developed by Micromet Inc, which was acquired by Amgen.[1]

Adecatumumab has been used in clinical studies of treatment in colorectal, prostate[2] and breast cancers.[3] Phase II results were published in 2010.[4]

References

http://adisinsight.springer.com/drugs/800013072%5B%5D
Oberneder, Ralf; Weckermann, Dorothea; Ebner, Beatrice; Quadt, Cornelia; Kirchinger, Petra; Raum, Tobias; Locher, Mathias; Prang, Nadja; Baeuerle, Patrick A.; Leo, Eugen (2006). "A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients". European Journal of Cancer. 42 (15): 2530–8. doi:10.1016/j.ejca.2006.05.029. PMID 16930989.
Prang, N; Preithner, S; Brischwein, K; Göster, P; Wöppel, A; Müller, J; Steiger, C; Peters, M; Baeuerle, P A; Da Silva, A J (2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". British Journal of Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc.6602310. PMC 2361858. PMID 15655555.
Schmidt, M.; Scheulen, M. E.; Dittrich, C.; Obrist, P.; Marschner, N.; Dirix, L.; Schmidt, M.; Ruttinger, D.; Schuler, M.; Reinhardt, C.; Awada, A. (2009). "An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer". Annals of Oncology. 21 (2): 275–82. doi:10.1093/annonc/mdp314. PMID 19633042.

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[1] ttp://adisinsight.springer.com/drugs/800013072%5B%5D

[pmid16930989-2] Oberneder, Ralf; Weckermann, Dorothea; Ebner, Beatrice; Quadt, Cornelia; Kirchinger, Petra; Raum, Tobias; Locher, Mathias; Prang, Nadja; Baeuerle, Patrick A.; Leo, Eugen (2006). "A phase I study with adecatumumab, a human antibody directed against epithelial cell adhesion molecule, in hormone refractory prostate cancer patients". European Journal of Cancer. 42 (15): 2530–8. doi:10.1016/j.ejca.2006.05.029. PMID 16930989.

[pmid15655555-3] Prang, N; Preithner, S; Brischwein, K; Göster, P; Wöppel, A; Müller, J; Steiger, C; Peters, M; Baeuerle, P A; Da Silva, A J (2005). "Cellular and complement-dependent cytotoxicity of Ep-CAM-specific monoclonal antibody MT201 against breast cancer cell lines". British Journal of Cancer. 92 (2): 342–9. doi:10.1038/sj.bjc.6602310. PMC 2361858. PMID 15655555.

[4] Schmidt, M.; Scheulen, M. E.; Dittrich, C.; Obrist, P.; Marschner, N.; Dirix, L.; Schmidt, M.; Ruttinger, D.; Schuler, M.; Reinhardt, C.; Awada, A. (2009). "An open-label, randomized phase II study of adecatumumab, a fully human anti-EpCAM antibody, as monotherapy in patients with metastatic breast cancer". Annals of Oncology. 21 (2): 275–82. doi:10.1093/annonc/mdp314. PMID 19633042.