Respirovirus

Respirovirus is a genus of viruses in the order Mononegavirales, in the family Paramyxoviridae[2]. Rodents and human serve as natural hosts. There are currently six species in this genus including the type species Murine respirovirus.[3] Diseases associated with this genus include: croup and other acute febrile respiratory tract infections.[4]

Respirovirus
Virus classification
(unranked): Virus
Realm: Riboviria
Phylum: Negarnaviricota
Class: Monjiviricetes
Order: Mononegavirales
Family: Paramyxoviridae
Subfamily: Orthoparamyxovirinae
Genus: Respirovirus
Type species
*Murine respirovirus
Species
  • Bovine respirovirus 3
  • Caprine respirovirus 3
  • Human respirovirus 1
  • Human respirovirus 3
  • Murine respirovirus
  • Porcine respirovirus 1
Synonyms[1]
  • Paramyxovirus

Structure

Respirovirions are enveloped, with spherical geometries. The diameter is around 150 nm. Respirovirus genomes are linear, around 15kb in length. The genome codes for 8 proteins.[3][4]

GenusStructureSymmetryCapsidGenomic arrangementGenomic segmentation
RespirovirusSphericalEnvelopedLinearMonopartite

Life cycle

Viral replication is cytoplasmic. Entry into the host cell is achieved by virus attaches to host cell. Replication follows the negative stranded RNA virus replication model. Negative stranded RNA virus transcription, using polymerase stuttering is the method of transcription. Translation takes place by leaky scanning, and ribosomal shunting. The virus exits the host cell by budding. Rodents and human serve as the natural host. Transmission routes are respiratory.[3][4]

GenusHost detailsTissue tropismEntry detailsRelease detailsReplication siteAssembly siteTransmission
RespirovirusRodents; humansNoneGlycoproteinBuddingCytoplasmCytoplasmAerosols

References
  1. Pringle, C. R. (1998). "Virus taxonomy-San Diego 1998" (PDF). Archives of Virology. 143 (7): 1449–59. doi:10.1007/s007050050389. PMID 9742051.
  2. Rima, B; Balkema-Buschmann, A; Dundon, WG; Duprex, P; Easton, A; Fouchier, R; Kurath, G; Lamb, R; Lee, B; Rota, P; Wang, L; ICTV Report Consortium (December 2019). "ICTV Virus Taxonomy Profile: Paramyxoviridae". The Journal of General Virology. 100 (12): 1593–1594. doi:10.1099/jgv.0.001328. PMID 31609197.
  3. "ICTV Report Paramyxoviridae".
  4. "Viral Zone". ExPASy. Retrieved 15 June 2015.

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