Cyclopenthiazide
Cyclopenthiazide (trade name Navidrex) is a thiazide diuretic used in the treatment of heart failure and hypertension.
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| ECHA InfoCard | 100.010.920  |
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| Formula | C13H18ClN3O4S2 |
| Molar mass | 379.88 g/mol g·mol−1 |
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Synthesis
Cyclopenthiazide synthesis:[1]
Contraindications
Thiazide diuretics increase the excretion of sodium and potassium ions and decrease the excretion of calcium ions and uric acid so they are contraindicated in patients with hyponatraemia, hypokalaemia, hypercalcaemia and hyperuricaemia. They are also contraindicated in patients with Addison's disease.
References
- Whitehead, C. W.; Traverso, J. J.; Sullivan, H. R.; Marshall, F. J. (1961). "Diuretics. V. 3,4-Dihydro-1,2,4-benzothiadiazine 1,1-Dioxides". The Journal of Organic Chemistry. 26 (8): 2814. doi:10.1021/jo01066a046.
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