Satavaptan

Satavaptan
Clinical data
ATC code	none;
Identifiers
	IUPAC name N-(tert-butyl)-4-{[(1s,4s)-5'-ethoxy-4-(2-morpholin-4-ylethoxy)-2'-oxospiro[cyclohexane-1,3'-indol]-1'(2'H)-yl]sulfonyl}-3-methoxybenzamide;
CAS Number	185913-78-4 ;
PubChem CID	9810773;
ChemSpider	32699105 ;
UNII	AJS8S3P31H;
ECHA InfoCard	100.211.853
Chemical and physical data
Formula	C33H45N3O8S
Molar mass	643.789 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1COCCN1CCO[C@H]2CC[C@](CC2)3c4cc(OCC)ccc4N(C3=O)S(=O)(=O)c5ccc(cc5OC)C(=O)NC(C)(C)C;
	InChI InChI=1S/C33H45N3O8S/c1-6-43-25-8-9-27-26(22-25)33(13-11-24(12-14-33)44-20-17-35-15-18-42-19-16-35)31(38)36(27)45(39,40)29-10-7-23(21-28(29)41-5)30(37)34-32(2,3)4/h7-10,21-22,24H,6,11-20H2,1-5H3,(H,34,37)/t24-,33+ ; Key:QKXJWFOKVQWEDZ-VCCCEUOBSA-N ;
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Satavaptan (INN; developmental code name SR121463, former tentative brand name Aquilda) is a vasopressin-2 receptor antagonist[1] which was investigation by Sanofi-Aventis and was under development for the treatment of hyponatremia. It was also being studied for the treatment of ascites.[2] Development was discontinued in 2009.[3]

References

Soupart A, Gross P, Legros JJ, et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol. 1 (6): 1154–1160. doi:10.2215/CJN.00160106. PMID 17699341.
Ginès P; Wong F; Watson H; Milutinovic S; Ruiz Del Arbol L; Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology. 48 (1): 204–213. doi:10.1002/hep.22293. PMID 18508290.
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[pmid17699341-1] Soupart A, Gross P, Legros JJ, et al. (November 2006). "Successful long-term treatment of hyponatremia in syndrome of inappropriate antidiuretic hormone secretion with satavaptan (SR121463B), an orally active nonpeptide vasopressin V2-receptor antagonist". Clin J Am Soc Nephrol. 1 (6): 1154–1160. doi:10.2215/CJN.00160106. PMID 17699341.

[pmid18508290-2] Ginès P; Wong F; Watson H; Milutinovic S; Ruiz Del Arbol L; Olteanu D (February 2008). "Effects of satavaptan, a selective vasopressin V(2) receptor antagonist, on ascites and serum sodium in cirrhosis with hyponatremia: A randomized trial". Hepatology. 48 (1): 204–213. doi:10.1002/hep.22293. PMID 18508290.

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