Selepressin
Selepressin (INN) (code name FE-202158), also known as [Phe(2),Ile(3), Hgn(4),Orn(iPr)(8)]vasopressin) is a potent, highly selective, short-acting peptide full agonist of the vasopressin 1A receptor and analog of vasopressin which was under development by Ferring Pharmaceuticals for the treatment of vasodilatory hypotension in septic shock.[1][2][3][4]
![]() | |
Clinical data | |
---|---|
Other names | H-Cys(1)-Phe-Ile-hGln-Asn-Cys(1)-Pro-Orn(iPr)-Gly-NH2 |
ATC code |
|
Identifiers | |
IUPAC name
| |
CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C46H73N13O11S2 |
Molar mass | 1048.282 g/mol gยทmolโ1 |
3D model (JSmol) | |
SMILES
| |
InChI
|
The Phase 2b/3 adaptive trial (SEPSIS-ACT) was terminated in February 2018 for futility. The trial was halted prior to the initiation of the arm for the highest dosing regimen of 5.0 ng/kg/min.[5]
References
- Jeremy I Levin (24 October 2014). Macrocycles in Drug Discovery. Royal Society of Chemistry. pp. 313โ. ISBN 978-1-84973-701-2.
- Jean-Louis Vincent (23 September 2012). Annual Update in Intensive Care and Emergency Medicine 2012. Springer Science & Business Media. pp. 80โ. ISBN 978-3-642-25716-2.
- J. L. Vincent (2 September 2008). Yearbook of Intensive Care and Emergency Medicine 2008. Springer Science & Business Media. pp. 427โ. ISBN 978-3-540-77290-3.
- Laporte, R.; Kohan, A.; Heitzmann, J.; Wisniewska, H.; Toy, J.; La, E.; Tariga, H.; Alagarsamy, S.; Ly, B.; Dykert, J.; Qi, S.; Wisniewski, K.; Galyean, R.; Croston, G.; Schteingart, C. D.; Riviere, P. J.- M. (2011). "Pharmacological Characterization of FE 202158, a Novel, Potent, Selective, and Short-Acting Peptidic Vasopressin V1a Receptor Full Agonist for the Treatment of Vasodilatory Hypotension". Journal of Pharmacology and Experimental Therapeutics. 337 (3): 786โ796. doi:10.1124/jpet.111.178848. ISSN 0022-3565. PMID 21411496.
- "Selepressin Evaluation Programme for Sepsis-Induced Shock - Adaptive Clinical Trial - Full Text View - ClinicalTrials.gov". clinicaltrials.gov. Retrieved 2019-06-07.
This article is issued from
Wikipedia.
The text is licensed under Creative
Commons - Attribution - Sharealike.
Additional terms may apply for the media files.