Chlorothiazide

Chlorothiazide, sold under the brand name Diuril among others, is an organic compound used as a diuretic and as an antihypertensive.[1]

Chlorothiazide
Clinical data
Trade namesDiuril, others
AHFS/Drugs.comMonograph
MedlinePlusa682341
Pregnancy
category
  • US: C (Risk not ruled out)
    Routes of
    administration
    By mouth, IV
    ATC code
    Legal status
    Legal status
    Pharmacokinetic data
    Bioavailabilitylow
    MetabolismNil
    Elimination half-life45 to 120 minutes
    ExcretionRenal
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    DrugBank
    ChemSpider
    UNII
    KEGG
    ChEBI
    ChEMBL
    CompTox Dashboard (EPA)
    ECHA InfoCard100.000.368
    Chemical and physical data
    FormulaC7H6ClN3O4S2
    Molar mass295.72 g/mol g·mol−1
    3D model (JSmol)
      (verify)

    It is used both within the hospital setting or for personal use to manage excess fluid associated with congestive heart failure. Most often taken in pill form, it is usually taken orally once or twice a day. In the ICU setting, chlorothiazide is given to diurese a patient in addition to furosemide (Lasix). Working in a separate mechanism than furosemide, and absorbed enterically as a reconstituted suspension administered through a nasogastric tube (NG tube), the two drugs potentiate one another.

    It was patented in 1956 and approved for medical use in 1958.[2]

    Indications

    Contraindications

    Side effects

    History

    The Research team of Merck Sharp and Dohme Research Laboratories of Beyer, Sprague, Baer, and Novello created a new series of medications, the thiazide diuretics, which includes chlorothiazide. They won an Albert Lasker Special Award in 1975 for this work.[4]

    References

    1. Ernst, Michael E.; Grimm, Richard H., Jr. "Thiazide diuretics: 50 years and beyond" Current Hypertension Reviews 2008, volume 4(4), pp. 256-265. doi:10.2174/157340208786241264
    2. Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 456. ISBN 9783527607495.
    3. "Diuril (Chlorothiazide): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 2019-10-07.
    4. Foundation, Lasker. "Historical Awards - The Lasker Foundation". The Lasker Foundation.
    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.