Trypanocidal agent

A trypanocidal agent is an antiprotozoal agent that acts upon trypanosome parasites.[1]

Examples include:[2]

See also

Trypanosomiasis vaccine

References

Trypanocidal+Agents at the US National Library of Medicine Medical Subject Headings (MeSH)
MeSH list of agents 82014344
GOBLE, F. C. (January 1950). "Chemotherapy of experimental trypanosomiasis; trypanocidal activity of certain bis (2-methyl-4-amino-6-quinolyl) amides and ethers". Journal of Pharmacology and Experimental Therapeutics. 98 (1): 49–61. PMID 15403620.

Antiparasitics – antiprotozoal agents – Chromalveolate antiparasitics (P01)

Conoidasida/
(Coccidiostats)

Cryptosporidiosis	thiazolides (nitazoxanide)
Isosporiasis	trimethoprim/sulfamethoxazole^#
Toxoplasmosis	pyrimethamine sulfadiazine clindamycin atovaquone

Malaria

Individual
agents

Hemozoin
inhibitors

Aminoquinolines	(4-): amodiaquine^# chloroquine^# hydroxychloroquine^# (8-): primaquine^# pamaquine^‡ tafenoquine^†
4-Methanolquinolines	mefloquine^# quinine^# quinidine
Other	lumefantrine + artemether^# halofantrine

DHFR inhibitors	pyrimethamine biguanides chlorproguanil proguanil^#
Sulfonamides	sulfadoxine sulfalene
Co-formulation	sulfadoxine/pyrimethamine (SP)^#

Sesquiterpene
lactones

Other

Combi-
nations

Fixed-dose (co-formulated) ACTs	artemether/lumefantrine^# arterolane/piperaquine artesunate/amodiaquine (ASAQ) artesunate/mefloquine (ASMQ) artesunate/pyronaridine dihydroartemisinin/piperaquine
Other combinations (not co-formulated)	artesunate/mefloquine artesunate/SP quinine/clindamycin quinine/doxycycline quinine/tetracycline

clindamycin

Cilio-
phora

Balantidiasis: tetracycline

Hetero-
kont

Blastocystosis: metronidazole

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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