Pyronaridine

Pyronaridine
Clinical data
Other names	Pyronaridine tetraphosphate
Routes of; administration	Oral, intramuscular injection, intravenous therapy
ATC code	none;
Legal status
Legal status	CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413);
Identifiers
	IUPAC name 4-[(7-Chloro-2-methoxy-pyrido[3,2-b]quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol;
CAS Number	74847-35-1 ;
PubChem CID	5485198;
ChemSpider	10647812 ;
UNII	TD3P7Q3SG6;
ChEMBL	ChEMBL35228 ;
Chemical and physical data
Formula	C29H32ClN5O2
Molar mass	518.06 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc6c(c1)nc2ccc(OC)nc2c6Nc5cc(CN3CCCC3)c(O)c(CN4CCCC4)c5;
	InChI InChI=1S/C29H32ClN5O2/c1-37-26-9-8-24-28(33-26)27(23-7-6-21(30)16-25(23)32-24)31-22-14-19(17-34-10-2-3-11-34)29(36)20(15-22)18-35-12-4-5-13-35/h6-9,14-16,36H,2-5,10-13,17-18H2,1H3,(H,31,32) ; Key:DJUFPMUQJKWIJB-UHFFFAOYSA-N ;
(what is this?) (verify)

Pyronaridine is an antimalarial drug.[1] It was first made in 1970 and has been in clinical use in China since the 1980s.[2]

It is one of the components of the artemisinin combination therapy pyronaridine/artesunate (Pyramax).[3]

It has also been studied as a potential anticancer drug.[4]

References

Croft, Simon L.; Duparc, Stephan; Arbe-Barnes, Sarah J.; Craft, J.; Shin, Chang-Sik; Fleckenstein, Lawrence; Borghini-Fuhrer, Isabelle; Rim, Han-Jong (2012). "Review of pyronaridine anti-malarial properties and product characteristics". Malaria Journal. 11: 270. doi:10.1186/1475-2875-11-270. PMC 3483207. PMID 22877082.
Chang C, Lin-Hua T, Jantanavivat C (1992). "Studies on a new antimalarial compound: pyronaridine". Trans R Soc Trop Med Hyg. 86 (1): 7–10. doi:10.1016/0035-9203(92)90414-8. PMID 1566313.
"Pyramax" (PDF). European Medicines Agency. 2016.
Villanueva, Paulina J.; Martinez, Alberto; Baca, Sarah T.; Dejesus, Rebecca E.; Larragoity, Manuel; Contreras, Lisett; Gutierrez, Denisse A.; Varela-Ramirez, Armando; Aguilera, Renato J. (2018). "Pyronaridine exerts potent cytotoxicity on human breast and hematological cancer cells through induction of apoptosis". PLOS ONE. 13 (11): e0206467. doi:10.1371/journal.pone.0206467. PMC 6218039. PMID 30395606.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.