8-Aminoquinoline

8-Aminoquinoline
Names
	IUPAC name Quinolin-8-amine
Identifiers
CAS Number	578-66-5 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL99932 ;
ChemSpider	10881 ;
ECHA InfoCard	100.008.572
PubChem CID	11359;
UNII	U34EAV21TG ;
CompTox Dashboard (EPA)	DTXSID4060369 ;
	InChI InChI=1S/C9H8N2/c10-8-5-1-3-7-4-2-6-11-9(7)8/h1-6H,10H2 Key: WREVVZMUNPAPOV-UHFFFAOYSA-N ;
	SMILES Nc1cccc2cccnc12;
Properties
Chemical formula	C9H8N2
Molar mass	144.177 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

8-Aminoquinoline is the 8-amino derivative of quinoline. It is structurally analogous to 8-hydroxyquinoline. The two nitrogen atoms are ideally situated to form complexes with metal ions. Derivatives of 8-aminoquinoline are effective directing groups in organic synthesis.[1][2]

Derivatives

The derivatives primaquine, tafenoquine and pamaquine have been tested for anti-malaria activity.[3][4]. Primaquine is still used routinely worldwide as part of the treatment of Plasmodium vivax and Plasmodium ovale malaria. Tafenoquine is currently in Phase III clinical trials and is not yet available to prescribe.

References

Daugulis, Olafs; Roane, James; Tran, Ly Dieu (2015). "Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds". Accounts of Chemical Research. 48 (4): 1053–1064. doi:10.1021/ar5004626. PMC 4406856. PMID 25756616.
Corbet, Matthieu; De Campo, Floryan (2013). "8-Aminoquinoline: A Powerful Directing Group in Metal-Catalyzed Direct Functionalization of C-H Bonds". Angewandte Chemie International Edition. 52 (38): 9896–9898. doi:10.1002/anie.201303556. PMID 23939922.
Nqoro, Xhamla; Tobeka, Naki; Aderibigbe, Blessing (2017). "Quinoline-Based Hybrid Compounds with Antimalarial Activity". Molecules. 22 (12): 2268. doi:10.3390/molecules22122268. PMC 6149725. PMID 29257067.
Sweeney AW; Blackburn CRB; KH Rieckmann (1 August 2004). "Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains)". Am J Trop Med Hyg. 71 (2): 187–189. PMID 15306708.

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[1] Daugulis, Olafs; Roane, James; Tran, Ly Dieu (2015). "Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds". Accounts of Chemical Research. 48 (4): 1053–1064. doi:10.1021/ar5004626. PMC 4406856. PMID 25756616.

[2] Corbet, Matthieu; De Campo, Floryan (2013). "8-Aminoquinoline: A Powerful Directing Group in Metal-Catalyzed Direct Functionalization of C-H Bonds". Angewandte Chemie International Edition. 52 (38): 9896–9898. doi:10.1002/anie.201303556. PMID 23939922.

[3] Nqoro, Xhamla; Tobeka, Naki; Aderibigbe, Blessing (2017). "Quinoline-Based Hybrid Compounds with Antimalarial Activity". Molecules. 22 (12): 2268. doi:10.3390/molecules22122268. PMC 6149725. PMID 29257067.

[4] Sweeney AW; Blackburn CRB; KH Rieckmann (1 August 2004). "Short report: The activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains)". Am J Trop Med Hyg. 71 (2): 187–189. PMID 15306708.