Naftifine

Naftifine
Clinical data
Trade names	Exoderil
AHFS/Drugs.com	Monograph
MedlinePlus	a688020
ATC code	D01AE22 (WHO) ;
Identifiers
	IUPAC name (2E)-N-methyl-N-(1-naphthylmethyl)-3-phenylprop-2-en-1-amine;
CAS Number	65472-88-0 ;
PubChem CID	47641;
DrugBank	DB00735 ;
ChemSpider	66071 ;
UNII	4FB1TON47A;
ChEBI	CHEBI:7451 ;
ChEMBL	ChEMBL626 ;
CompTox Dashboard (EPA)	DTXSID6048545 ;
Chemical and physical data
Formula	C21H21N
Molar mass	287.398 g/mol g·mol−1
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Naftifine (brand name Exoderil) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (fungal infections).

Naftifine has triple action: antifungal, antibacterial and anti-inflammatory. Its precise mechanism of action is unknown, but may involve selectively blocking sterol biosynthesis via inhibition of the squalene 2,3-epoxidase enzyme.[1][2] The half-life is approximately 2–3 days.[2] The metabolites are excreted in the urine and feces.[3]

References

Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.
Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.
AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.

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[Robertson-1] Robertson Dirk B, Maibach Howard I, "Chapter 61. Dermatologic Pharmacology" (Chapter). Bertram G. Katzung, Susan B. Masters, Anthony J. Trevor: Basic & Clinical Pharmacology, 11e: http://www.accesspharmacy.com/content.aspx?aID=4517257.

[Micromedex-2] Micromedex DRUGDEX Drug Point: Naftifine Hydrochloride. Accessed at www.thomsonhc.com/../BeginWith#secN10184, February 18, 2010.

[3] AccessPharmacy: Drug Monographs: Naftifine. Accessed at http://www.accesspharmacy.com/drugContentPopup.aspx?mid=6620&section=10, February 18, 2010.