Isoconazole

Isoconazole
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	D01AC05 (WHO) G01AF07 (WHO);
Identifiers
	IUPAC name (RS)-1-[2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
CAS Number	27523-40-6;
PubChem CID	3760;
DrugBank	DB08943 ;
ChemSpider	3629;
UNII	GRI7WFR424;
KEGG	D04624;
ChEBI	CHEBI:82865 ;
ChEMBL	ChEMBL1571863;
CompTox Dashboard (EPA)	DTXSID7045447 ;
ECHA InfoCard	100.044.084
Chemical and physical data
Formula	C18H14Cl4N2O
Molar mass	416.127 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(c(Cl)c1)C(OCc2c(Cl)cccc2Cl)Cn3ccnc3;

Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]

It was patented in 1968 and approved for medical use in 1979.[5]

References

Veraldi, Stefano (May 2013). "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses. 56 Suppl 1: 3–15. doi:10.1111/myc.12054. ISSN 1439-0507. PMID 23574019.
The Merck Index, 12th Edition, 5176
Oyeka, C.A.; Gugnani H.C. (1992). "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses. 35 (11–12): 357–61. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.
Cohen, L. (1984). "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". Retrieved 2008-05-23.
Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 502. ISBN 9783527607495.

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