Micronomicin

Micronomicin
Clinical data
Other names	(2R,3R,4R,5R)-2-[(1S,2S,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol
AHFS/Drugs.com	International Drug Names
Routes of; administration	Eye drops, IV
ATC code	S01AA22 (WHO) ;
Legal status
Legal status	In general: ℞ (Prescription only);
Identifiers
	IUPAC name (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-D-erythro-hexopyranoside;
CAS Number	52093-21-7;
PubChem CID	107677;
ChemSpider	2301017;
UNII	S9AZ0R40QV;
KEGG	D08219 ;
Chemical and physical data
Formula	C20H41N5O7
Molar mass	463.56 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H](C([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CNC)N)N)N)O;
	InChI InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1; Key:DNYGXMICFMACRA-XHEDQWPISA-N;
(verify)

Micronomicin (INN) is an aminoglycoside antibiotic for use on the eye.[1][2]

References

Odakura, Y.; Kase, H.; Nakayama, K. (1983). "Sagamicin and the related aminoglycosides: Fermentation and biosynthesis. III. Isolation and characterization of Micromonospora sagamiensis mutants blocked in gentamicin C1 pathway". The Journal of Antibiotics. 36 (2): 125–130. doi:10.7164/antibiotics.36.125. PMID 6833127.
Fukuda, M.; Sasaki, K. (2002). "Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous". Nippon Ganka Gakkai Zasshi. 106 (4): 195–200. PMID 11979978.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.