MFZ 10-7

MFZ 10-7
Identifiers
	IUPAC name 3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile;
ChemSpider	26334163;
ChEMBL	ChEMBL1784608;
Chemical and physical data
Formula	C15H9FN2
Molar mass	236.244
3D model (JSmol)	Interactive image;
	SMILES Cc1cccc(n1)C#Cc2cc(cc(c2)F)C#N;
	InChI InChI=1S/C15H9FN2/c1-11-3-2-4-15(18-11)6-5-12-7-13(10-17)9-14(16)8-12/h2-4,7-9H,1H3; Key:ZGEXQIMQZVRTDZ-UHFFFAOYSA-N;

MFZ 10-7 (3-fluoro-5-((6-methylpyridin-2-yl)ethynyl)benzonitrile) is a negative allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5). Others of the kind, namely MPEP & MTEP, are not considered to have translational potential for human use due to off-target effects and short half-lives. Drugs of this kind have been used to offset craving for drugs of abuse such as cocaine in in vivo animal administration models.[1]

References

Keck, Thomas M.; Zou, Mu-Fa; Bi, Guo-Hua; Zhang, Hai-Ying; Wang, Xiao-Fei; Yang, Hong-Ju; Srivastava, Ratika; Gardner, Eliot L.; Xi, Zheng-Xiong; Newman, Amy Hauck (2014). "A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats". Addiction Biology. 19 (2): 195–209. doi:10.1111/adb.12086. ISSN 1355-6215. PMC 3942387.

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[KeckZou2014-1] Keck, Thomas M.; Zou, Mu-Fa; Bi, Guo-Hua; Zhang, Hai-Ying; Wang, Xiao-Fei; Yang, Hong-Ju; Srivastava, Ratika; Gardner, Eliot L.; Xi, Zheng-Xiong; Newman, Amy Hauck (2014). "A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats". Addiction Biology. 19 (2): 195–209. doi:10.1111/adb.12086. ISSN 1355-6215. PMC 3942387.

MFZ 10-7

See also

References