Remeglurant

Remeglurant
Clinical data
Other names	MRZ-8456
ATC code	None;
Identifiers
	IUPAC name (6-Bromopyrazolo[1,5-a]pyrimidin-2-yl)[(1R)-1-methyl-3,4-dihydro-2(1H)-isoquinolinyl]methanone;
CAS Number	1309783-00-3;
PubChem CID	24810684;
ChemSpider	32701693;
Chemical and physical data
Formula	C17H15BrN4O
Molar mass	371.231 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H]1c2ccccc2CCN1C(=O)c3cc4ncc(cn4n3)Br;
	InChI InChI=1S/C17H15BrN4O/c1-11-14-5-3-2-4-12(14)6-7-21(11)17(23)15-8-16-19-9-13(18)10-22(16)20-15/h2-5,8-11H,6-7H2,1H3/t11-/m1/s1; Key:TUYZYSNXXSTKQX-LLVKDONJSA-N;

Remeglurant (INN; developmental code name MRZ-8456) is a drug which acts as a selective antagonist of the mGlu₅ receptor.[1][2][3] It is under development by Merz Pharmaceuticals for the treatment of drug-induced dyskinesia but no development has been reported since at least 2016.[3]

References

World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 109" (PDF). WHO Drug Information. World Health Organization. 27 (2).
Danysz W, et al. Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators. US Patent 7985753, 4 August 2006.
http://adisinsight.springer.com/drugs/800045269

External links

Remeglurant - AdisInsight

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[WHO2013-1] World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN): Proposed INN: List 109" (PDF). WHO Drug Information. World Health Organization. 27 (2).

[Danysz2006-2] Danysz W, et al. Substituted pyrazolo[1,5-A]pyrimidines as metabotropic glutamate receptor modulators. US Patent 7985753, 4 August 2006.

[AdisInsight-3] ttp://adisinsight.springer.com/drugs/800045269

Remeglurant

See also

References

External links