Gadofosveset

Gadofosveset trisodium
Clinical data
Trade names	Vasovist, Ablavar
Pregnancy; category	US: C (Risk not ruled out) ;
Routes of; administration	Intravenous
ATC code	V08CA11 (WHO) ;
Legal status
Legal status	US: ℞-only ;
Identifiers
	IUPAC name Trisodium 2-{[(2R)-2-[bis(2-oxido-2-oxoethyl)amino]-3-[(4,4-diphenylcyclohexyl)oxy-oxidophosphoryl]oxypropyl]-[2-[bis(2-oxido-2-oxoethyl)amino]ethyl]amino}acetate;
CAS Number	211570-55-7 ; 193901-90-5 (anhydrous);
PubChem CID	158440;
DrugBank	DB06705;
ChemSpider	139381;
UNII	XM33Q67UVH;
KEGG	D08005 ;
Chemical and physical data
Formula	C33H40GdN3Na3O15P
Molar mass	975.88 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Gd+3].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)C[C@@H](N(CC([O-])=O)CC([O-])=O)COP([O-])(=O)OC3CCC(c1ccccc1)(c2ccccc2)CC3.O;
	InChI InChI=1S/C33H44N3O14P.Gd.3Na.H2O/c37-28(38)18-34(15-16-35(19-29(39)40)20-30(41)42)17-26(36(21-31(43)44)22-32(45)46)23-49-51(47,48)50-27-11-13-33(14-12-27,24-7-3-1-4-8-24)25-9-5-2-6-10-25;;;;;/h1-10,26-27H,11-23H2,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H,47,48);;;;;1H2/q;+3;3*+1;/p-6/t26-;;;;;/m1...../s1; Key:PIZALBORPSCYJU-QSQMUHTISA-H;

Gadofosveset (trade names Vasovist, Ablavar) is a gadolinium-based MRI contrast agent. It was used as the trisodium salt monohydrate form.[1][2] It acts as a blood pool agent by binding to human serum albumin. The manufacturer (Lantheus Medical) discontinued production in 2017 due to poor sales.[3]

References

DailyMed: Vasovist
Drugs.com: Ablavar
Bell, Daniel; Morgan, Matt. "Gadofosveset trisodium". Radiopaedia. radiopaedia.org. Retrieved 2018-08-28.

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