Iodixanol

Iodixanol is an iodine-containing non-ionic radiocontrast agent. It is sold under the trade name Visipaque; it is also sold as a density gradient medium under the name OptiPrep.[1] Visipaque is commonly used as a contrast agent during coronary angiography. It is the only iso-osmolar contrast agent, with an osmolality of 290 mOsm/kg H₂O, the same as blood. It is sold in 2 main concentrations 270 mgI/ml and 320 mgI/ml - hence the name Visipaque 270 or 320. It is sold in single dose units and a large 500ml plastic bottle for multi-dose dispensing.

Iodixanol

Clinical data
Other names	5-[acetyl-[3-[acetyl-[3,5-bis(2,3-dihydroxypropylcarbamoyl)-2,4,6-triiodo-phenyl]amino]-2-hydroxy-propyl]amino]-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-benzene-1,3-dicarboxamide
AHFS/Drugs.com	Multum Consumer Information
ATC code	V08AB09 (WHO)
Pharmacokinetic data
Protein binding	Negligible
Metabolism	Excreted unchanged
Elimination half-life	2.1 hours
Excretion	Renal
Identifiers
IUPAC name 5-{N-[3-(N-{3,5-bis[(2,3-dihydroxypropyl)carbamoyl]-2,4,6-triiodophenyl}acetamido)-2-hydroxypropyl]acetamido}-1-N,3-N-bis(2,3-dihydroxypropyl)-2,4,6-triiodobenzene-1,3-dicarboxamide
CAS Number	92339-11-2 Y
PubChem CID	3724
DrugBank	DB01249 Y
ChemSpider	3593 Y
UNII	HW8W27HTXX
KEGG	D01474 Y
ChEBI	CHEBI:31705 Y
ChEMBL	ChEMBL1200507 N
CompTox Dashboard (EPA)	DTXSID2045523
ECHA InfoCard	100.124.306
Chemical and physical data
Formula	C35H44I6N6O15
Molar mass	1550.191 g·mol−1
3D model (JSmol)	Interactive image
SMILES Ic1c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c(I)c1N(C(=O)C)CC(O)CN(C(=O)C)c2c(I)c(c(I)c(c2I)C(=O)NCC(O)CO)C(=O)NCC(O)CO
InChI InChI=1S/C35H44I6N6O15/c1-13(52)46(30-26(38)20(32(59)42-3-15(54)9-48)24(36)21(27(30)39)33(60)43-4-16(55)10-49)7-19(58)8-47(14(2)53)31-28(40)22(34(61)44-5-17(56)11-50)25(37)23(29(31)41)35(62)45-6-18(57)12-51/h15-19,48-51,54-58H,3-12H2,1-2H3,(H,42,59)(H,43,60)(H,44,61)(H,45,62) Y Key:NBQNWMBBSKPBAY-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

It was originally made by Nycomed, which then merged with Amersham which finally was bought by Jeff Immelt to become GE Healthcare. The majority of Visipaque is made in Cork, Ireland, with additional plants in China and Oslo. All Iodixanol bulk powder is made in Norway by GE Healthcare.

A very similar product also manufactured by GE Healthcare is Omnipaque (Iohexol as the main drug substance).

Iodixanol is also the active ingredient in a number of 'cushion' products used during the centrifugation of stallion semen. It is layered underneath the extended stallion semen allowing for a higher g force to be used with less sperm damage and better recovery rates. Post centrifugation the supernatant above and the cushion below is removed, leaving a concentrated sperm pellet in the conical tube. [2]